Shanxi Province cervical cancer screening study II: Self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology
Shanxi Province cervical cancer screening study II: Self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology
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DOI：
10.1111/j.1525-1438.2003.13611.x
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发表时间：
2003-11-01
影响因子：
4.8
通讯作者：
Fife, D
中科院分区：
文献类型：
--
作者：
Belinson, JL;Qiao, YL;Fife, D
本研究的目的是比较高危人乳头瘤病毒 (HPV) 自我取样新方法与直接取样和液基宫颈细胞学检查的敏感性和特异性。在中国山西省，8,497 名女性（27 至 56 岁）使用锥形刷插入阴道上部并旋转，进行了 HPV 自我采样。三到十六个月后，这些女性接受了液基细胞学检查和直接 HPV 检测。任何异常测试的受试者均接受阴道镜检查和多次活检。平均年龄为 40.9 岁。 4.4% 的受试者的 CIN II 大于或等于，26% 的受试者自身样本呈阳性，24% 的受试者 HPV 直接检测呈阳性。自采样检测大于或等于 CIN II 的灵敏度为 87.5%，直接检测灵敏度为 96.8%（P < 0.001）。自检样本的特异性为 77.2%，直接测试的特异性为 79.7%。对于定义为 ASCUS 或更高的异常巴氏涂片，巴氏涂片检测大于或等于 CIN II 的敏感性为 88.3%，特异性为 81.2%。我们得出的结论是，HPV 自我取样对 >CIN II 的敏感性低于直接检测，但与液基细胞学相似。
The objective of this study was to compare the sensitivity and specificity of a new method for self-sampling for high risk human papillomavirus (HPV) with direct sampling and liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27-56) underwent a self-sample for HPV using a conical-shaped brush placed into the upper vagina and rotated. Three to sixteen months later the women were screened with liquid-based cytology and direct HPV tests. Subjects with any abnormal test underwent colposcopy and multiple biopsies. Mean age was 40.9 years. 4.4 percent of subjects had greater than or equal toCIN II, 26% a positive self-sample and 24% a positive direct test for HPV. The sensitivity for detection of greater than or equal toCIN II was 87.5% for self-sampling, and 96.8% for the direct test (P < 0.001). The specificity was 77.2% for the self-sample and 79.7% for the direct test. With an abnormal Pap defined as ASCUS or greater the sensitivity of the Pap for the detection of greater than or equal toCIN II was 88.3% and the specificity was 81.2%. We conclude that self-sampling for HPV is less sensitive for >CIN II than the direct test, but similar to liquid based cytology.