Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever
Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever
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DOI：
10.1038/4007
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发表时间：
1998-12-01
期刊：
影响因子：
82.9
通讯作者：
Kwiatkowski, D
中科院分区：
文献类型：
--
作者：
Vidal, V;Scragg, IG;Kwiatkowski, D
肿瘤坏死因子的大量释放是造成潜在致命的贾里施-赫克斯海默反应的原因，该反应是在抗生素治疗复发伯氏疏螺旋体引起的回归热后发生的。我们对复发芽孢杆菌刺激人单核细胞产生肿瘤坏死因子的成分进行了定量纯化。我们发现诱导肿瘤坏死因子的主要因子是与赫氏芽孢杆菌的可变主要蛋白同源的可变脂蛋白。我们在两名虱传回归热患者中发现了针对不同形式的可变主要蛋白的抗体。这里研究的三种纯化的可变主要蛋白在诱导肿瘤坏死因子产生的能力上有所不同，这可能部分解释了疏螺旋体感染的不同临床严重程度。这些结果可能与莱姆病和其他形式的人类疏螺旋体病的发病机制具有相当大的相关性。
Massive release of tumor necrosis factor is responsible for the potentially fatal jarisch-Herxheimer reaction that follows antibiotic treatment of relapsing fever due to Borrelia recurrentis. We have undertaken the quantitative purification of the components of B. recurrentis that stimulate human monocytes to produce tumor necrosis factor. We show that the predominant factor inducing tumor necrosis factor is a variable lipoprotein homologous to the variable major protein of B. hermsii. We found antibodies to different forms of variable major protein in two patients with louse-borne relapsing fever. The three purified variable major proteins studied here differ in their ability to induce tumor necrosis factor production, which may partly explain the variable clinical severity of borrelial infection. These results may be of considerable relevance for the pathogenesis of Lyme disease and other forms of human borreliosis.