Hepatitis C-Associated Cryoglobulinemic Glomerulonephritis With Crystalline Deposits
Hepatitis C-Associated Cryoglobulinemic Glomerulonephritis With Crystalline Deposits
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DOI：
10.1053/j.ajkd.2013.02.354
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发表时间：
2013-08-01
影响因子：
13.2
通讯作者：
Lassman, Charles R.
中科院分区：
文献类型：
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作者：
Khalighi, Mazdak A.;Lassman, Charles R.
丙型肝炎病毒感染与许多肝外表现有关，包括肾脏疾病。在丙型肝炎病毒感染引起的肾小球病理状态中，冷球蛋白血症性肾小球肾炎是最常见的。在肾活检中，冷球蛋白血症性肾小球肾炎的表现各不相同，最常见的光学显微镜发现是膜增殖性损伤模式。从超微结构上看，弯曲和成对的微管是最具特征性的发现，但这些也可能是可变的。我们介绍一例冷球蛋白血症性肾小球肾炎病例，其超微结构表现明显且极不寻常。 (C) 2013 年，国家肾脏基金会 (National Kidney Foundation, Inc.)
Infection with hepatitis C virus has been associated with a number of extrahepatic manifestations, including kidney disease. Of the glomerular pathologic states described with hepatitis C virus infection, cryoglobulinemic glomerulonephritis is the most prevalent. On kidney biopsy, cryoglobulinemic glomerulonephritis has a variable appearance, with a membranoproliferative pattern of injury as the most common light microscopic finding. Ultrastructurally, curved and paired microtubules are the most characteristic finding, but these also can be variable. We present a case of cryoglobulinemic glomerulonephritis with distinct and highly unusual ultrastructural findings. (C) 2013 by the National Kidney Foundation, Inc.