Electrophysiology of vagal afferents: amino acid detection in the gut.

Electrophysiology of vagal afferents: amino acid detection in the gut.
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迷走神经传入的电生理学:肠道中的氨基酸检测。

DOI:
10.1111/j.1749-6632.2009.03907.x
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发表时间:
2009
影响因子:
5.2
通讯作者:
Horn,CharlesC
Horn,CharlesC
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Horn,CharlesC

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消化道包括嘴、胃和肠,并由数千个化学感觉神经元与大脑相连。与对舌味系统的理解相比,对消化道其他区域的化学感觉功能的洞察很少。胃肠道中已知的味觉感受器的存在表明了与口腔中存在的味觉机制相似。迷走神经的传入纤维在向后脑发送胃肠道化学物质的信号方面起着重要作用,这一信息可以用来引发防御反应,如呕吐或营养反应。迷走神经传入纤维可能检测到大量氨基酸,但这些刺激的最初感觉转导和功能意义仍然是个谜。本文讨论了记录迷走神经传入电生理信号的几个问题,特别是十二指肠和肝区传入信号的采集。
The alimentary canal includes the mouth, stomach, and intestines, and is connected to the brain by thousands of chemosensory neurons. In contrast to the understanding of the lingual taste system, there is little insight into the chemosensory function of other regions of the alimentary canal. The presence of known taste receptors in the gastrointestinal tract suggests a similarity to taste mechanisms present in the oral cavity. Afferent fibers of the vagus play a prominent role in signaling the chemical contents of the gastrointestinal tract to the hindbrain and this information can be used to elicit defensive responses, such as vomiting or nutritional responses. A host of amino acids are likely detected by vagal afferent fibers, but the initial sensory transduction of these stimuli and functional significance remains a mystery. Several problems with recording the electrophysiological signals of vagal afferents are discussed, with particular reference to sampling the afferent signals from the duodenum and liver region.
通过用 3-溴丙酸修饰半胱氨酸残基 174 灭活马肝乙醇脱氢酶。
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