A COMPUTER-PROGRAM FOR PREDICTING PROTEIN ANTIGENIC DETERMINANTS
A COMPUTER-PROGRAM FOR PREDICTING PROTEIN ANTIGENIC DETERMINANTS
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DOI：
10.1016/0161-5890(83)90029-9
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
WOODS, KR
中科院分区：
文献类型：
--
作者：
HOPP, TP;WOODS, KR
本文提出了一种预测蛋白质抗原决定簇位置的计算机方法，该方法只需要蛋白质的氨基酸序列而不需要其它信息。该程序已用于预测乙型肝炎B表面抗原的主要抗原决定簇以及一系列已知抗原结构的测试蛋白上的抗原位点（Hopp和Wood，1981）。该方法适用于较小的个人计算机，并以BASIC语言编写，以使其可用于计算机经验和/或资源有限的调查人员。以流感血凝素为例，说明了在同源系列蛋白质上定位多个抗原位点的方法。
A computerized method for predicting the locations of protein antigenic determinants is presented, which requires only the amino acid sequence of a protein and no other information. This procedure has been used to predict the major antigenic determinant of the hepatitis B surface antigen, and antigenic sites on a series of test proteins of known antigenic structure (Hopp and Wood, 1981). The method is suitable for use in smaller personal computers and is written in the BASIC language to make it available to investigators with limited computer experience and/or resources. A means of locating multiple antigenic sites on a homologous series of proteins is demonstrated using the influenza hemagglutinin as an example.