Clinical profile of diabetic ketoacidosis in adults
Clinical profile of diabetic ketoacidosis in adults
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成人糖尿病酮症酸中毒的临床特征
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
R. Reddy
中科院分区：
文献类型：
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作者：
V D Rao;B. Pradhan;Y. Mallikarjuna;R. Reddy
简介：糖尿病酮症酸中毒（DKA）是糖尿病的一种可能危及生命的并发症。最近的流行病学研究表明，在美国DKA的住院治疗正在增加。印度的流行病学研究有限。我们进行了这项观察性研究，以分析印度南部成人DKA的临床特征。方法：本研究于2010年8月至2011年7月在安得拉邦的一家三级护理中心进行。DKA的诊断是通过存在（1）血糖水平250 mg/dl或更高（2）血清碳酸氢盐水平15 mEq/lt或更低（3）动脉血pH值7.3或更低或静脉血pH值7.25或更低（4）存在中度或大量尿酮。所有患者均接受机构治疗方案。结果：27例患者中，2型糖尿病22例（81%），1型糖尿病5例（19%），女性10例，男性17例。年龄18 ~ 70岁，平均45.3岁。60%的入院患者存在死亡因素。在50%的患者中观察到不依从或停止药物治疗。结论：1型糖尿病患者的平均住院时间略长于2型糖尿病患者，其中很大一部分DKA发生在2型糖尿病患者中，通过适当的患者教育和与医疗保健提供者的有效沟通，可以预防其中许多病例。DOI：http://dx.doi.org/10.3126/hren.v10i2.6569 Health Renaissance 2012; 2012年10月（第2期）; 80-86
Introduction: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Recent epidemiological studies indicate that hospitalizations for DKA in the U.S. are increasing. Epidemiological studies from India are limited. We undertook this observational study to analyse the clinical profiles of DKA in adults in south India. Methods: This study was conducted in at a tertiary care center in Andhra Pradesh for one year from Aug 2010 to July 2011. Diagnosis of DKA was made by the presence of (1) Plasma glucose level of 250mg/dl or higher (2) Serum bicarbonate level of 15mEq/lt or lower (3) Arterial blood pH of 7.3 or lower or a venous blood pH of 7.25 or lower (4) Presence of moderate or large urine ketones. All the patients were treated with institutional treatment protocol. Results: Of 27 patients, 22(81%) had type2 diabetes and 5(19%) had type 1 DM .10 were females and 17 males. Age of the patients ranged between 18 to 70 years, with an average of 45.3 years. Precipitating factors were present in 60% of the admissions. Non-compliance or discontinuation of drug therapy was seen in fifty per cent of patients. Average length of hospital stay was slightly longer in type 1 than type 2 DM patients Conclusion: A significant proportion of DKA occurs in patients with type 2 diabetes and many of these cases can be prevented with proper patient education and effective communication with a health care provider during an inter-current illness. DOI: http://dx.doi.org/10.3126/hren.v10i2.6569 Health Renaissance 2012; Vol 10 (No.2); 80-86