POPULATION PHARMACOKINETICS OF RACEMIC WARFARIN IN ADULT PATIENTS
POPULATION PHARMACOKINETICS OF RACEMIC WARFARIN IN ADULT PATIENTS
复制标题
DOI：
10.1007/bf01065653
复制
发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
CRAWFORD, MH
中科院分区：
文献类型：
--
作者：
MUNGALL, DR;LUDDEN, TM;CRAWFORD, MH
使用来自32名成人住院患者和131名成人门诊患者的613个华法林血浆浓度测量值评价外消旋华法林的群体药代动力学。使用高效液相色谱法，一式两份测量Warcantine浓度。使用的药代动力学模型为一室开放模型，具有一级吸收（吸收速率常数设定为47天-1）和一级消除。假设可用性程度为1。线性回归模型用于评估各种人口统计学因素对华法林口服清除率的影响。在该成人人群中，年龄似乎是华法林清除率的重要决定因素。在20-70岁的年龄范围内，口服清除率每年下降约1%。吸烟似乎导致华法林清除率增加10%，而同时给予诱导剂苯妥英或苯巴比妥使清除率增加约30%。这项研究已经产生了一个预测模型，当结合适当的药理学反应数据，可能是有用的华法林方案的设计和调整。
The population pharmacokinetics of racemic warfarin was evaluated using 613 measured warfarin plasma concentrations from 32 adult hospitalized patients and 131 adult outpatients. Warfarin concentrations were measured in duplicate using a high-performance liquid chromatographic procedure. The pharmacokinetic model used was a one-compartment open model with first-order absorption (absorption rate constant set equal to 47 day-1) and first-order elimination. The extent of availability was assumed to be one. A linear regression model was used to evaluate the influence of various demographic factors on warfafin oral clearance. Age appeared to be an important determinant of warfarin clearance in this adult population. There was about a 1%/year decrease in oral clearance over the age range of 20-70 years. Smoking appeared to result in a 10% increase in warfarin clearance, while coadministration of the inducers phenytoin or phenobarbital yielded about a 30% increase in clearance. This study has yielded a predictive model that, when combined with appropriate pharmacological response data, may be useful in the design and adjustment of warfarin regimens.