SHORT-TERM-MEMORY AND TEMPORAL ORDERING IN EARLY PARKINSONS-DISEASE - EFFECTS OF DISEASE CHRONICITY AND MEDICATION
SHORT-TERM-MEMORY AND TEMPORAL ORDERING IN EARLY PARKINSONS-DISEASE - EFFECTS OF DISEASE CHRONICITY AND MEDICATION
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DOI：
10.1016/0028-3932(93)90149-t
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发表时间：
1993-09-01
期刊：
影响因子：
2.6
通讯作者：
SULLIVAN, EV
中科院分区：
文献类型：
--
作者：
COOPER, JA;SAGAR, HJ;SULLIVAN, EV
帕金森氏病（PD）的研究表明，受损的时间顺序，但解释可能会混淆的任务要求和药物的影响。我们研究了项目识别和近因歧视在PD治疗和其他测试的性能。患者表现出反应潜伏期增加和受损的近因歧视，只有在短的保留时间间隔。赤字更大的慢性药物治疗的患者，但左旋多巴，溴隐亭或抗胆碱能药物治疗并不影响新诊断病例的性能。短期记忆缺陷与工作记忆、注意力和执行功能测试的分数相关。这些结果并不表明PD中的普遍时间顺序缺陷，但表明该疾病中的大部分认知障碍来自影响短期和工作记忆的注意力缺陷。
Studies of Parkinson's disease (PD) have shown impaired temporal ordering but interpretation may be confounded by task requirements and the effects of medication. We examined item recognition and recency discrimination in PD in relation to treatment and performance on other tests. Patients showed increased response latency and impaired recency discrimination only at short retention intervals. The deficits were greater in chronically medicated patients but treatment with levodopa, bromocriptine or anticholinergic drugs did not affect performance of newly diagnosed cases. The short-term memory deficits correlated with scores on tests of working memory, attention and executive function. These results do not indicate a generalised temporal ordering deficit in PD but suggest that much of the cognitive impairment in the disorder arises from attentional deficits affecting short-term and working memory.