Effects of selective estrogen receptor agonists on food intake and body weight gain in rats
Effects of selective estrogen receptor agonists on food intake and body weight gain in rats
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DOI：
10.1016/j.physbeh.2005.08.035
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发表时间：
2006-01-30
影响因子：
2.9
通讯作者：
Roesch, DM
中科院分区：
文献类型：
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作者：
Roesch, DM
卵巢切除 (OVX) 大鼠比假手术 (SO) 大鼠吃得更多且体重增加更快，雌二醇 (E-2) 治疗可减弱 OVX 大鼠的食物摄入量和体重增加。研究旨在检验以下假设：雌激素受体 (ER α) 的 α 亚型介导 E-2 对食物摄入和体重增加的减弱作用，而 β 亚型 (ER) 介导导致食物摄入增加和体重增加的相反作用。雌性大鼠为SO或OVX，每天用媒介物（二甲基亚砜，DMSO）或E-2（10μg/天）或ERα选择性激动剂、4,4',4"-(4-丙基-[1H]-吡唑-1,3,5-三基）三酚（PPT，0.5mg/天）或ER选择性激动剂治疗， 2,3-双(4-羟基苯基)-丙腈（DPN，0.5 mg/天）持续 14 天，与 SO 大鼠相比，OVX 大鼠的总食物摄入量显着减少，但 DPN 没有显着增加，并且用 E-2 或 PPT（但不是 DPN）治疗，显着降低总体体重增加至与 SO 大鼠没有显着差异的水平。 0.25 mg/天的 PPT 显着降低了 21 天的总食物摄入量和体重增加，与 OVX 大鼠相比，0.13 和 0.06 mg/天的 PPT 显着降低了总体体重增加，但没有显着减少了总食物摄入量。 DPN 的剂量反应研究表明，三种剂量的 DPN 均未显着改变 2 1 天的总食物摄入量或总体体重增加。这些结果表明 ER α 介导了 ER α 的减弱作用。雌激素对食物摄入量和体重增加有影响，而 ERO 对这些变量没有影响 (c) 2005 Elsevier Inc. 保留所有权利。
Ovariectomized (OVX) rats eat more and gain weight more rapidly than sham-operated (SO) rats and estradiol (E-2) treatment attenuates food intake and body weight gain in OVX rats. Studies were designed to test the hypothesis that the alpha subtype of the estrogen receptor (ER alpha) mediates the attenuating effects of E-2 on food intake and body weight gain while the beta subtype (ER) mediates opposing actions that lead to increased food intake and body weight gain. Female rats were SO or OVX and treated daily with vehicle (dimethylsulfoxide, DMSO) or E-2 (10 mu g/day), or the ER alpha-selective agonist, 4,4',4"-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT, 0.5 mg/day), or the ER-selective agonist, 2,3-bis(4-hyroxyphenyl)-propionitrile (DPN, 0.5 mg/day) for 14 days. Total food intake was significantly reduced by E-2 and PPT, but not DPN. Total body weight gain was significantly increased in OVX rats compared to SO rats and treatment with E-2 or PPT, but not DPN, significantly decreased total body weight gain to levels that were not significantly different from SO rats. A dose-response study of PPT indicated that at 0.25 mg/day, PPT significantly reduced total 21-day food intake and body weight gain and, at 0.13 and 0.06 mg/day, PPT significantly reduced total body weight gain compared to OVX rats without significantly reducing total food intake. A dose-response study of DPN indicated that none of the three doses of DPN significantly altered total 2 1-day food intake or total body weight gain. These results suggest ER alpha mediates the attenuating effects of estrogens on food intake and body weight gain while ERO has no effect on these variables. (c) 2005 Elsevier Inc. All rights reserved.