PLATELET-DERIVED GROWTH-FACTOR PROMOTES SMOOTH-MUSCLE MIGRATION AND INTIMAL THICKENING IN A RAT MODEL OF BALLOON ANGIOPLASTY
PLATELET-DERIVED GROWTH-FACTOR PROMOTES SMOOTH-MUSCLE MIGRATION AND INTIMAL THICKENING IN A RAT MODEL OF BALLOON ANGIOPLASTY
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DOI：
10.1172/jci115613
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发表时间：
1992-02-01
影响因子：
15.9
通讯作者：
CLOWES, AW
中科院分区：
文献类型：
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作者：
JAWIEN, A;BOWENPOPE, DF;CLOWES, AW
血小板源性生长因子（PDGF）在体外是血管平滑肌细胞（SMC）的有丝分裂原和趋化剂，但其体内活性很大程度上仍不清楚。 我们将重组 PDGF-BB（每次静脉注射 0.01-0.30 毫克/千克）注入颈动脉损伤的大鼠体内。 PDGF-BB 使内侧 SMC 增殖小幅增加（两到三倍）。 更重要的是，PDGF-BB在损伤后的前7天内大大增加了内膜增厚和SMC从中膜到内膜的迁移（20倍）。 这些数据支持了以下假设：PDGF 以及其他血小板因子可能在间充质细胞移动到正在修复的损伤区域中发挥重要作用。
Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.