EFFECTS OF AGING ON PAIN RESPONSES AND ANALGESIC EFFICACY OF MORPHINE AND CLONIDINE IN RATS
EFFECTS OF AGING ON PAIN RESPONSES AND ANALGESIC EFFICACY OF MORPHINE AND CLONIDINE IN RATS
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DOI：
10.1016/0014-4886(82)90011-5
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发表时间：
1982-01-01
影响因子：
5.3
通讯作者：
LAI, YY
中科院分区：
文献类型：
--
作者：
CHAN, SHH;LAI, YY
本实验用3组不同年龄的大鼠（54.4 ± 0.5），观察了衰老过程中大鼠痛反应的变化及吗啡和可乐定的镇痛效果。1.2，162.2 .+-。3.7和327.8 .+-。1.7天，平均值±。SE），使用热板测定作为伤害感受试验。老龄大鼠热板潜伏期逐渐缩短，吗啡和可乐定的镇痛效力逐渐降低，这种变化似乎与脑内儿茶酚胺和乙酰胆碱含量的下降，以及多巴胺、乙酰胆碱和阿片受体浓度的下降有关。这些结果的作用，髓核网状apertocellularis作为一个共同的神经基板的疼痛抑制和镇痛促进吗啡和可乐定的影响。
Changes in pain response and the analgesic efficacy of morphine and clonidine during senescence were studied in 3 groups of rats with different ages (54.4 .+-. 1.2, 162.2 .+-. 3.7, and 327.8 .+-. 1.7 days, mean .+-. SE), using the hot plate assay as the nociceptive test. A progressive decrease in the hot plate latency, and a gradual reduction in the analgesic potency of morphine and clonidine in aging rats was found. Such changes appear to be related to a decline in the content of catecholamines and acetylcholine, as well as a decrease in concentrations of dopamine, acetylcholine, and opiate receptors in the aging brain. These results have implications for the role of the medullary nucleus reticularis gigantocellularis as a common neural substrate for pain suppression and analgesia promoted by morphine and clonidine.