Serial transplantation of bone marrow to test self-renewal capacity of hematopoietic stem cells in vivo.
Serial transplantation of bone marrow to test self-renewal capacity of hematopoietic stem cells in vivo.
复制标题
连续骨髓移植以测试体内造血干细胞的自我更新能力。
DOI：
10.1007/978-1-62703-317-6_2
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zhang,Hong
中科院分区：
文献类型：
--
作者：
Ramkumar,Charusheila;Gerstein,RachelM;Zhang,Hong
造血干细胞（HSC）具有自我更新和补充血液和免疫系统的能力，用于个体的寿命。与年龄相关的HSC功能下降是老年人免疫功能下降和骨髓疾病和贫血发病率增加的原因。HSC功能的变化被认为是HSC随着年龄的增长自我更新潜力的内在缺陷的结果。在这一章中，我们描述了一个骨髓系列移植方案，旨在测试体内造血干细胞的自我更新能力。
Hematopoietic stem cells (HSCs) have the ability to self-renew and replenish the blood and immune system for the life span of an individual. An age-associated decline in HSC function is responsible for the decreased immune function and increased incidence of myeloid diseases and anemia in the elderly. The changes in HSC function are thought to occur as the result of an intrinsic defect in the self-renewal potential of HSCs as they age. In this chapter, we describe a bone marrow serial transplantation protocol designed to test the self-renewal capacity of HSCs in vivo.