Electrospun nanofibers for microfluidic analytical systems
Electrospun nanofibers for microfluidic analytical systems
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DOI：
10.1016/j.polymer.2011.05.026
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发表时间：
2011-07-07
期刊：
影响因子：
4.6
通讯作者：
Frey, Margaret W.
中科院分区：
文献类型：
--
作者：
Cho, Daehwan;Matlock-Colangelo, Lauren;Frey, Margaret W.
嵌有功能聚合物的纳米纤维表现出带电的表面。将这些纤维并入微流体通道中以在微流体系统内提供高表面积和功能表面。将亲水性聚乙烯醇分别与带有胺基或羧基的功能性聚合物共混，制备了带正电荷或负电荷的纳米纤维。X射线光电子能谱（XPS）和傅里叶变换红外光谱（FTIR）被用来确认共混物组分在纺丝纤维中的存在和位置。热刺激电流（TSC）的测量证实，表面带电的纳米纤维显示出正或负的电流，根据功能聚合物嵌入的PVA聚合物。将表面带电的纳米纤维并入微流体通道中。聚（乙烯醇）（PVA）的共混物纳米纤维，制定创造纤维表面化学的变化，静电纺丝形成图案周围的金微电极上的聚（甲基丙烯酸甲酯）（PMMA）芯片表面。将这些微流控图案集成到基于聚合物的微流控通道中，以创建具有生物分析潜在应用的功能化微流控系统。优化了纺丝条件和微电极，以使纳米纤维能够在微流体通道上对齐。重要的是，组装好的微流体通道内的纳米纤维很坚固，在线速度高达13.6 mm/s的极端流体流动条件下不会断裂或从通道中冲出。(C)2011爱思唯尔有限公司保留所有权利。
Nanofibers embedded with the functional polymers exhibited a charged surface. These fibers were incorporated into microfluidic channels to provide high surface area and functional surfaces within a microfluidic system. The positively or negatively charged nanofibers were fabricated by blending of hydrophilic PVA with functional polymers with available amine groups or carboxyl groups, respectively. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) were used to confirm the presence and location of blend components in the spun fibers. Thermally stimulated current (TSC) measurements confirmed that surface-charged nanofibers showed positive or negative currents according to the functional polymers embedded with the PVA polymer. The surface-charged nanofibers were incorporated into microfluidic channels. Poly(vinyl alcohol) (PVA) blend nanofibers formulated to create variations in fiber surface chemistry were electrospun to form patterns around gold microelectrodes on a poly(methyl methacrylate) (PMMA) chip surface. These nanofiber patterns were integrated into polymer-based microfluidic channels to create a functionalized microfluidic system with potential applications in bioanalysis. Spinning conditions and microelectrodes were optimized to enable an alignment of the nanofibers across the microfluidic channel. Importantly, nanofibers within the assembled microfluidic channels were robust and did not break or wash out of the channel under extreme fluid flow conditions at linear velocities up to 13.6 mm/s. (C) 2011 Elsevier Ltd. All rights reserved.