Preferential Noradrenergic Innervation of Alpha‐Adrenergic Receptors in Vascular Smooth Muscle
Preferential Noradrenergic Innervation of Alpha‐Adrenergic Receptors in Vascular Smooth Muscle
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DOI：
10.1161/01.hyp.3.3_pt_2.i112
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发表时间：
1981-05
期刊：
影响因子：
8.3
通讯作者：
S. Z. Langer;N. Shepperson;R. Massingham
中科院分区：
文献类型：
--
作者：
S. Z. Langer;N. Shepperson;R. Massingham
在离体犬后肢灌流标本中，对去甲肾上腺素（NE）的升压反应是由突触后α，β-和肾上腺素能受体介导的。使用优先的AR和rtradrenergic受体拮抗剂获得的结果表明，c$-亚型主要受神经支配，而血管平滑肌中的a，-和a$肾上腺素能受体亚型都可被循环激动剂和拮抗剂所接受。在离体灌注猫脾的初步研究支持这些在狗体内的发现。与血管平滑肌相反，猫瞬膜似乎只含有α，β-肾上腺素能受体突触后。（高血压3（增刊I）：1-112-1-118，1981）
SUMMARY In the isolated perfused hindlimb preparation of the dog, pressor responses to norepinephrine (NE) are mediated by postsynaptic a,- and aradrenergic receptors. Results obtained using preferential ar and rtradrenergic receptor antagonists suggest that the c$-subtype is predominantly innervated while both a,- and a$adrenergic receptor subtypes in vascular smooth muscle are accessible to circulating agonists and antagonists. Preliminary studies in the isolated perfused cat spleen support these in rivo findings in the dog. In contrast to vascular smooth muscle, the cat nictitating membrane appears to contain only a,-adrenergic receptors postsynaptically. (Hypertension 3 (supp I): 1-112-1-118, 1981)