The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence.
The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence.
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DOI：
10.1371/journal.pbio.1002236
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发表时间：
2015-08
期刊：
影响因子：
9.8
通讯作者：
Boots M
中科院分区：
文献类型：
--
作者：
Boots M
毫无疑问，进化在通过抗生素和杀虫剂耐药性防止控制传染病方面发挥了重要作用，但最近的理论表明，疾病干预措施，如疫苗接种可能导致更有害的寄生虫的进化。Andrew Read及其同事在PLOS Biology上发表的一项新研究表明，根据经验，针对马立克氏病的疫苗接种有利于更高的毒力;如果不进行干预，鸟类死亡太快，无法发生任何传播，但接种疫苗的宿主可以存活更长时间并摆脱病毒。这是一个优雅的经验证明进化理论如何预测传染病对人类干预的潜在危险反应。来自马立克氏病研究的新证据支持进化理论，该理论表明疫苗接种可以选择增加寄生虫毒力。
There is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disease interventions such as vaccination may lead to evolution of more harmful parasites. A new study published in PLOS Biology by Andrew Read and colleagues shows empirically that vaccination against Marek’s disease has favored higher virulence; without intervention, the birds die too quickly for any transmission to occur, but vaccinated hosts can both stay alive longer and shed the virus. This is an elegant empirical demonstration of how evolutionary theory can predict potentially dangerous responses of infectious disease to human interventions. New evidence from studies of Marek’s disease supports evolutionary theory, which suggests that vaccination can select for increased parasite virulence.