Hypsugopoxvirus: A Novel Poxvirus Isolated from Hypsugo savii in Italy
Hypsugopoxvirus: A Novel Poxvirus Isolated from Hypsugo savii in Italy
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DOI：
10.3390/v11060568
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发表时间：
2019-06-01
期刊：
影响因子：
4.7
通讯作者：
Moreno, Ana
中科院分区：
文献类型：
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作者：
Lelli, Davide;Lavazza, Antonio;Moreno, Ana
在过去的十年里，人们对蝙蝠相关病毒的兴趣大大增加，导致在几个蝙蝠物种中发现了越来越多的新病毒。痘病毒科是一个大的、多样化的DNA病毒家族，可以感染广泛的脊椎动物和无脊椎动物。到目前为止，在三个不同的大陆(美洲、非洲和澳大利亚)的蝙蝠种群中只有几个有案可查的检测到痘病毒。这些病毒在系统发育上是不同的，对宿主有不同的临床影响。在此，我们报道了从意大利北部一种食虫蝙蝠(Hypsugo Savii)中发现的一种新的痘病毒的分离、几乎完全的基因组测序和注释。这种病毒暂时被命名为HypsugopoxVirus(HYPV)，以它被分离出来的蝙蝠物种的名字命名。基因组全长为166,600个核苷酸，编码161个基因。基因组分析表明，HYPV属于Chordopoxvirinae亚家族，与2011年在美国华盛顿州发现的EB病毒(Eptesicus Fuscus)的核苷酸同源性最高(85%)。到目前为止，HYPV是欧洲第一个在蝙蝠身上检测到的痘病毒；因此，它的病毒生态学和疾病相关性应该得到进一步的调查。
Interest in bat-related viruses has increased considerably during the last decade, leading to the discovery of a rising number of new viruses in several bat species. Poxviridae are a large, diverse family of DNA viruses that can infect a wide range of vertebrates and invertebrates. To date, only a few documented detections of poxviruses have been described in bat populations on three different continents (America, Africa, and Australia). These viruses are phylogenetically dissimilar and have diverse clinical impacts on their hosts. Herein, we report the isolation, nearly complete genome sequencing, and annotation of a novel poxvirus detected from an insectivorous bat (Hypsugo savii) in Northern Italy. The virus is tentatively named Hypsugopoxvirus (HYPV) after the bat species from which it was isolated. The nearly complete genome size is 166,600 nt and it encodes 161 genes. Genome analyses suggest that HYPV belongs to the Chordopoxvirinae subfamily, with the highest nucleotide identity (85%) to Eptesipoxvirus (EPTV) detected from a microbat Eptesicus fuscus in WA, USA, in 2011. To date, HYPV represents the first poxvirus detected in bats in Europe; thus, its viral ecology and disease associations should be investigated further.