Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults
Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults
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DOI：
10.1086/341899
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发表时间：
2002-08-15
影响因子：
11.8
通讯作者：
Wynne, B
中科院分区：
文献类型：
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作者：
Finegold, SM;Flynn, MJ;Wynne, B
进行了一项开放标签、多中心研究，以评估与成人慢性细菌性上颌窦炎相关的细菌学结果。在基线（治疗前），从临床可评价患者中回收了70种需氧菌（52.2%）和64种厌氧菌（47.8%）。最常见的厌氧菌是普雷沃菌属（31.1%）、厌氧链球菌（21.9%）和梭杆菌属（15.6%）。最常回收的需氧菌包括链球菌（21.4%）、流感嗜血杆菌（15.7%）、铜绿假单胞菌（15.7%）、金黄色葡萄球菌和卡他莫拉菌（各10.0%）。当厌氧菌计数大于或等于10（3）cfu/mL时，与厌氧菌相关的细菌性上颌窦炎体征或症状复发的频率是与需氧菌相关的体征或症状复发的频率的两倍。首次记录了慢性鼻窦炎病例中Granulicatella物种的致病作用。
An open-label, multicenter study was performed to assess bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Seventy aerobic (52.2%) and 64 anaerobic (47.8%) pathogens were recovered from clinically evaluable patients at baseline (before therapy). The most commonly isolated anaerobes were Prevotella species (31.1%), anaerobic streptococci (21.9%), and Fusobacterium species (15.6%). The aerobes most frequently recovered included Streptococcus species (21.4%), Haemophilus influenzae (15.7%), Pseudomonas aeruginosa (15.7%), and Staphylococcus aureus and Moraxella catarrhalis (10.0% each). Recurrences of signs or symptoms of bacterial maxillary sinusitis associated with anaerobes were twice as frequent as were those associated with aerobes when counts of anaerobes were greater than or equal to10(3) cfu/mL. A pathogenic role for Granulicatella species in cases of chronic sinusitis was documented for the first time.