Risk of cancer other than Kaposi's sarcoma and non Hodgkin's lymphoma in persons with AIDS in Italy
Risk of cancer other than Kaposi's sarcoma and non Hodgkin's lymphoma in persons with AIDS in Italy
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DOI：
10.1038/bjc.1998.610
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发表时间：
1998-10-01
影响因子：
8.8
通讯作者：
Rezza, G
中科院分区：
文献类型：
--
作者：
Franceschi, S;Dal Maso, L;Rezza, G
在国家艾滋病登记处和13个癌症登记处之间进行了记录联系，1991年覆盖了约15%的意大利人口。在6067名艾滋病患者中评估了观察到的和预期的癌症数量和标准化发病率（SIRs），总共为25759人年。霍奇金病的SIRs显著升高[8.9,95%可信区间（CI） 4.4-16.0]，其中11例中有7例为混合细胞型；宫颈浸润性癌（15.5;95% CI 4.0-40.1）；非黑色素瘤皮肤癌（3.0,95% CI 1.3-5.9），其中8例中有5例为基底细胞癌。脑肿瘤也出现了过量，但这可能部分是由于在艾滋病诊断期间对脑部非霍奇金淋巴瘤或其他脑部疾病的误诊。在排除卡波西肉瘤（KS）和非霍奇金淋巴瘤（NHL）后，所有癌症类型的风险大约是一般人群风险的两倍。因此，艾滋病患者霍奇金病的SIR增加得到了证实，尽管它比NHL小很多倍。与宫颈浸润性癌的关联也显示在人群水平上。非黑色素瘤皮肤癌的发病率似乎低于移植受者。
Record linkage was carried out between the national Registry of AIDS and 13 Cancer Registries (CRs) covering, in 1991, about 15% of the Italian population. Observed and expected numbers of cancers and standardized incidence ratios (SIRs) were assessed in 6067 persons with AIDS, for a total of 25 759 person-years. Significantly increased SIRs were found for Hodgkin's disease [8.9, 95% confidence interval (CI) 4.4-16.0], in which seven of 11 cases were of mixed cellularity type; invasive carcinoma of the cervix uteri (15.5; 95% CI 4.0-40.1); and non-melanomatous skin cancer (3.0, 95% CI 1.3-5.9), in which five of eight cases were basal cell carcinoma. An excess was also seen for brain tumours, but this may be partly due to misdiagnosis of brain non-Hodgkin's lymphoma or other brain diseases occurring near the time of the AIDS diagnosis. The risk for all cancer types, after exclusion of Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL), was approximately twice the general population risk. An increased SIR for Hodgkin's disease in persons with AIDS is thus confirmed, though it is many times smaller than that for NHL. An association with invasive carcinoma of the cervix is also shown at a population level. The excess of non-melanomatous skin cancer seems to be lower than in transplant recipients.