POP-1 and anterior-posterior fate decisions in C-elegans embryos
POP-1 and anterior-posterior fate decisions in C-elegans embryos
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DOI：
10.1016/s0092-8674(00)80917-4
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发表时间：
1998-01-23
期刊：
影响因子：
64.5
通讯作者：
Priess, JR
中科院分区：
文献类型：
--
作者：
Lin, RL;Hill, RJ;Priess, JR
C.秀丽线虫胚胎执行谱系程序，其中细胞的命运与该细胞出生的分裂顺序可再现地相关。我们提供的证据表明，POP-1基因的功能，连接前后细胞分裂与细胞命运的决定。每个前细胞产生的前-后分裂似乎有一个更高水平的核POP-1蛋白比它的后姐妹。C.线虫Wnt途径是POP-1水平不平等所必需的。我们发现，pop-1（+）活性的丧失导致几种类型的前细胞采用其后姐妹篇的命运。这些结果提示了卵裂球谱系不变性的机制。
Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop-1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.