The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care units.
The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care units.
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DOI：
10.1186/cc7162
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Laupland K
中科院分区：
文献类型：
--
作者：
Stelfox HT;Ahmed SB;Khandwala F;Zygun D;Shahpori R;Laupland K
虽然钠干扰在住院患者中很常见，但很少有研究专门调查重症监护病房（ICU）钠干扰的流行病学。本研究的目的是描述ICU获得性低钠血症和高钠血症的发生率，并评估其对ICU预后的影响。我们确定了2000年1月1日至2006年12月31日期间入住三家内科-外科ICU的8142名连续成人（18岁或以上），他们在ICU入院第一天的血清钠水平正常（133至145 mmol/L）。ICU获得性低钠血症和高钠血症分别定义为在ICU第一天后血清钠浓度低于133 mmol/L或高于145 mmol/L。917例（11%）患者出现重症监护室获得性低钠血症，2157例（26%）患者出现高钠血症，在29142天ICU住院期间，发病率密度分别为3.1例和7.4例/ 100天。ICU获得性低钠血症（年龄、入院诊断、急性生理与慢性健康评估（APACHE） II评分、ICU住院时间、意识水平、血糖水平、体温、血钾水平）和ICU获得性高钠血症（基线肌酐、APACHE II评分、机械通气、ICU住院时间、体温、血钾水平、护理水平）的发生率根据患者的特点而有所不同。与血清钠水平正常的患者相比，icu获得性低钠血症患者（16%对28%，p < 0.001）和icu获得性高钠血症患者（16%对34%，p < 0.001）的住院死亡率增加。重症监护病房获得性低钠血症和高钠血症在危重患者中很常见，并与医院死亡风险增加有关。
Although sodium disturbances are common in hospitalised patients, few studies have specifically investigated the epidemiology of sodium disturbances in the intensive care unit (ICU). The objectives of this study were to describe the incidence of ICU-acquired hyponatraemia and hypernatraemia and assess their effects on outcome in the ICU. We identified 8142 consecutive adults (18 years of age or older) admitted to three medical-surgical ICUs between 1 January 2000 and 31 December 2006 who were documented to have normal serum sodium levels (133 to 145 mmol/L) during the first day of ICU admission. ICU acquired hyponatraemia and hypernatraemia were respectively defined as a change in serum sodium concentration to below 133 mmol/L or above 145 mmol/L following day one in the ICU. A first episode of ICU-acquired hyponatraemia developed in 917 (11%) patients and hypernatraemia in 2157 (26%) patients with an incidence density of 3.1 and 7.4 per 100 days of ICU admission, respectively, during 29,142 ICU admission days. The incidence of both ICU-acquired hyponatraemia (age, admission diagnosis, Acute Physiology and Chronic Health Evaluation (APACHE) II score, length of ICU stay, level of consciousness, serum glucose level, body temperature, serum potassium level) and ICU-acquired hypernatraemia (baseline creatinine, APACHE II score, mechanical ventilation, length of ICU stay, body temperature, serum potassium level, level of care) varied according to patients' characteristics. Compared with patients with normal serum sodium levels, hospital mortality was increased in patients with ICU-acquired hyponatraemia (16% versus 28%, p < 0.001) and ICU-acquired hypernatraemia (16% versus 34%, p < 0.001). ICU-acquired hyponatraemia and hypernatraemia are common in critically ill patients and are associated with increased risk of hospital mortality.
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影响因子：
0.9
作者：
Bennani, SL;Abouqal, R;Kerkeb, O
通讯作者：
Kerkeb, O
影响因子：
5.1
作者：
LONG, CA;MARIN, P;PATHY, MSJ
通讯作者：
PATHY, MSJ
DOI：
10.1111/j.1532-5415.1981.tb01761.x
发表时间：
1981-01-01
影响因子：
6.3
作者：
MAHOWALD, JM;HIMMELSTEIN, DU
通讯作者：
HIMMELSTEIN, DU
影响因子：
39.2
作者：
ANDERSON, RJ;CHUNG, HM;SCHRIER, RW
通讯作者：
SCHRIER, RW
影响因子：
--
作者：
CHUNG, HM;KLUGE, R;ANDERSON, RJ
通讯作者：
ANDERSON, RJ