Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
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DOI：
10.1038/ng.251
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发表时间：
2008-12-01
期刊：
影响因子：
30.8
通讯作者：
Hintzen, Rogier Q.
中科院分区：
文献类型：
--
作者：
Aulchenko, Yurii S.;Hoppenbrouwers, Ilse A.;Hintzen, Rogier Q.
The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
