Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma
Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma
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DOI：
10.1016/j.juro.2007.05.119
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发表时间：
2007-10-01
影响因子：
6.6
通讯作者：
Fujioka, Tomoaki
中科院分区：
文献类型：
--
作者：
Obara, Wataru;Konda, Ryuichiro;Fujioka, Tomoaki
目的：维生素D3的活性形式，即1 α，25-二羟基维生素D3，与维生素D受体结合，维生素D受体与类维生素A X受体α、β和γ形成复合物以显示抗肿瘤作用。我们研究了维生素D受体和维甲酸X受体在肾细胞癌中的表达，并阐明这些受体的预后意义。材料和方法：我们进行了免疫组化检测维生素D受体，维甲酸X受体α，β和γ在肾切除标本68例肾细胞癌。我们分析了这些受体的表达与临床病理参数或患者生存期之间的相关性。结果：维生素D受体、维甲酸X受体a和0的表达与临床病理参数无明显相关性。相反，类维生素A X受体γ表达与肿瘤分期（p = 0.009）和远处转移（p = 0.005）显著相关。肾细胞癌中RX-R γ阳性者的5年生存率高于RX-R γ阴性者（79.3%vs40.0%，p < 0.05）。考克斯回归分析显示，维甲酸X受体γ表达、肿瘤状态和淋巴结状态是影响肾癌患者预后的独立因素（p < 0.05）。维甲酸X受体γ的表达与肿瘤分期、远处转移和5年生存率显著相关。此外，类维生素A X受体γ表达是一个独立的预后因素，在患者肾细胞cancer.Conclusions：我们的观察表明，维生素D受体和类维生素A X受体表达的改变可能参与肾细胞癌的发生和类维生素A X受体γ表达可能是一个有用的预后指标，在肾细胞癌患者。
Purpose: The active form of vitamin D3, that is l alpha,25-dihydroxyvitamin D3, binds with vitamin D receptor, which forms a complex with retinoid X receptors a, 0 and gamma to manifest antitumor effects. We examined the expression of vitamin D receptor and retinoid X receptors in renal cell carcinoma and elucidated the prognostic significance of these receptors.Materials and Methods: We performed immunohistochemical examination of vitamin D receptor, and retinoid X receptors alpha, beta and gamma in nephrectomized specimens of 68 patients with renal cell carcinoma. We analyzed the correlation between the expression of these receptors and clinicopathological parameters or patient survival. Mean followup was 68.2 months.Results: No significant correlation was found between the expression of vitamin D receptor, retinoid X receptor a or 0 and clinicopathological parameters. In contrast, retinoid X receptor gamma expression correlated significantly with tumor stage (p = 0.009) and distant metastasis (p = 0.005). The 5-year cancer specific survival rate was higher in patients with retinoid X receptor gamma positive renal cell carcinoma than those with retinoid X receptor gamma negative renal cell carcinoma (79.3% vs 40.0%, p < 0.05). Cox regression analysis revealed that retinoid X receptor gamma expression, tumor status and lymph node status were significant independent prognostic factors in patients with renal cell carcinoma (p < 0.05). A significant correlation was observed between the expression of retinoid X receptor gamma and tumor stage, distant metastasis or the 5-year cancer specific survival rate. Furthermore, retinoid X receptor gamma expression was an independent prognostic factor in patients with renal cell carcinoma.Conclusions: Our observations suggest that alterations of vitamin D receptor and retinoid X receptor expression may be involved in renal carcinogenesis and retinoid X receptor gamma expression may be a useful prognostic marker in patients with renal cell carcinoma.