Spike coding mechanisms of cerebellar temporal processing in classical conditioning and voluntary movements
Spike coding mechanisms of cerebellar temporal processing in classical conditioning and voluntary movements
复制标题
经典条件反射和随意运动中小脑时间处理的尖峰编码机制
DOI：
10.1007/s12311-014-0580-5
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Yamaguchi;K. and Sakurai;Y.
时间是日常生活中的一个基本和关键因素。毫秒计时是说话、跳舞和其他活动的基本时间处理，据报道依赖于小脑。本文就小脑锋电位编码的时间加工机制进行综述。虽然小脑对经典条件反射和随意运动的贡献是众所周知的，但经典条件反射和随意运动之间的时间处理机制的差异尚不清楚。因此，我们回顾了经典条件反射和随意运动研究中小脑时间加工的证据，并报告了它们之间的异同。从一些研究，其中使用的任务，可以改变一些时间属性（例如，刺激间隔的持续时间）与保持相同的运动，我们得出结论，经典条件反射和随意运动可能共享一个共同的尖峰编码机制，因为浦肯野细胞中的简单尖峰在预测的反应时间减少，而不管反应或刺激之间的间隔。
Time is a fundamental and critical factor in daily life. Millisecond timing, which is the underlying temporal processing for speaking, dancing, and other activities, is reported to rely on the cerebellum. In this review, we discuss the cerebellar spike-coding mechanisms for temporal processing. Although the contribution of the cerebellum to both classical conditioning and voluntary movements is well known, the difference of the mechanisms for temporal processing between classical conditioning and voluntary movements is not clear. Therefore, we review the evidence of cerebellar temporal processing in studies of classical conditioning and voluntary movements and report the similarities and differences between them. From some studies, which used tasks that can change some of the temporal properties (e.g., the duration of interstimulus intervals) with keeping identical movements, we concluded that classical conditioning and voluntary movements may share a common spike-coding mechanism because simple spikes in Purkinje cells decrease at predicted times for responses regardless of the intervals between responses or stimulation.