Protection against challenge with measles virus (MV) in infant macaques by an MV DNA vaccine administered in the presence of neutralizing antibody.
Protection against challenge with measles virus (MV) in infant macaques by an MV DNA vaccine administered in the presence of neutralizing antibody.
复制标题
在中和抗体存在的情况下注射 MV DNA 疫苗，可保护幼年猕猴免受麻疹病毒 (MV) 的攻击。
DOI：
10.1086/420792
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
McChesney,MichaelB
中科院分区：
文献类型：
--
作者：
Premenko-Lanier,Mary;Rota,PaulA;Rhodes,GaryH;Bellini,WilliamJ;McChesney,MichaelB
麻疹病毒（MV）感染是全世界婴儿和儿童疫苗可预防死亡的主要原因。由于母体抗体的存在，在出生后6-9个月的婴儿中很难通过使用疫苗实现对MV感染的免疫。如果出生时接种的疫苗能够在母体抗体存在的情况下启动免疫，那么由MV感染引起的发病率和死亡率将大大降低。我们在这里证明，在母源抗体存在的情况下，将MV DNA疫苗接种给幼猴，会引发MV特异性T细胞反应，但不会引发新生中和抗体。该疫苗保护80%的幼猴免受皮疹和mv引起的免疫抑制。这种疫苗需要一种分子白介素-2佐剂来保护。该猕猴模型表明，在母体抗体存在的情况下，婴儿可以接种MV疫苗。这些结果表明，有可能开发出一种MV DNA疫苗，可以在生命的头几个月保护发展中国家的婴儿。
Measles virus (MV) infection is the major cause of vaccine-preventable death in infants and children worldwide. It is difficult to achieve immunity to MV infection by use of vaccines in infants during the first 6–9 months of life because of the presence of maternal antibody. Morbidity and mortality due to MV infection would decrease substantially if a vaccine administered at birth could prime immunity in the presence of maternal antibody.We demonstrate here that an MV DNA vaccine administered to infant macaques in the presence of maternal antibody primes MV-specific T cell responses but not de novo neutralizing antibody. This vaccine protected 80% of the infant macaques from skin rash and MV-induced immunosuppression. A molecular interleukin-2 adjuvant was required for protection with this vaccine. This macaque model shows that infants can be vaccinated against MV in the presence of maternal antibody. These results suggest that it is possible to develop an MV DNA vaccine that could protect infants in developing countries during the first months of life.