Prevalence of Asymptomatic Bacteriuria and Antimicrobial Resistance Profile among Pregnant Females in a Tertiary Care Hospital.
Prevalence of Asymptomatic Bacteriuria and Antimicrobial Resistance Profile among Pregnant Females in a Tertiary Care Hospital.
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DOI：
10.4103/ijcm.ijcm_792_20
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Bose S
中科院分区：
文献类型：
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作者：
Agarwal A;Pandey S;Maheshwari U;Singh MP;Srivastava J;Bose S
尿路感染（UTI）是妊娠期最常见的临床表现，如果是无症状菌尿（ASB），则可进展为肾盂肾炎，导致进一步的并发症。本研究旨在了解我院妊娠妇女ASB的患病率及耐药情况。共收集了552份孕妇（无UTI症状）的尿液样本，包括门诊和妇产科病房。在血琼脂、麦康凯琼脂和UTI显色琼脂上进行尿培养。采用纸片扩散法进行药敏试验，并对结果进行分析。孕妇ASB患病率为17.4%。以25-33岁年龄组多见（60.4%）。妊娠中期的感染率（43.7%）高于妊娠晚期（29.2%）和妊娠早期（27.1%）。妊娠期多产（60.4%）是ASB的常见发现。在孕妇中，与ASB相关的UTI（22.9%）和贫血（58.3%）既往史显著增加。大肠埃希菌（39.2%）是最常见的分离微生物，其次是金黄色葡萄球菌（34.3%）、粪肠球菌（14.7%）、克雷伯菌（4.9%）、凝固酶阴性葡萄球菌（14.7%）和葡萄球菌（14.7%）。(2.9柠檬酸杆菌属和不动杆菌属（1.9%）。妊娠期ASB最敏感的药物是呋喃妥因和磷霉素。强调应在产前早期进行尿培养作为常规筛查，以识别孕妇的ASB，因为它可以预防胎儿和母体并发症。
Urinary tract infection (UTI) is the most common clinical finding during pregnancy, and if it is asymptomatic bacteriuria (ASB), it can progress to pyelonephritis, leading to further complications. The present study aims to know the prevalence of ASB in pregnant females and the antimicrobial resistance pattern in our hospital setup. A total of 552 urine samples were collected from pregnant females (with no symptoms of UTI) both attending outpatient department and admitted in the wards of obstetrics and gynecology department. Urine culture was performed on blood agar, MacConkey agar, and UTI chromogenic agar. Antibiotic sensitivity test was done using Kirby-Bauer disc diffusion method, and the results were interpreted. The prevalence rate of ASB in pregnant females was 17.4%. It was common in the age group of 25–33 years (60.4%). The infection rate was higher in the second trimester (43.7%) compared to the third (29.2%) and first (27.1%) trimester. Multiparity (60.4%) was a common finding in ASB during pregnancy. There was a significant finding of previous history of UTI (22.9%) and anemia (58.3%) associated with ASB in pregnant females. Escherichia coli (39.2%) was the most common microorganism isolated followed by Staphylococcus aureus (34.3%), Enterococcus faecalis (14.7%), Klebsiella (4.9%), coagulase-negative Staphylococcus spp. (2.9%), and Citrobacter and Acinetobacter (1.9%). Most sensitive drugs to be given in ASB during pregnancy were nitrofurantoin and fosfomycin. It was emphasized that urine culture should be done in early antenatal visit as routine screening to identify ASB in pregnant females as it can prevent fetal and maternal complications.