Functional neural correlates of psychometric schizotypy: An fMRI study of antisaccades
Functional neural correlates of psychometric schizotypy: An fMRI study of antisaccades
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DOI：
10.1111/j.1469-8986.2011.01306.x
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发表时间：
2012-03-01
期刊：
影响因子：
3.7
通讯作者：
Ettinger, Ulrich
中科院分区：
文献类型：
--
作者：
Aichert, Desiree S.;Williams, Steven C. R.;Ettinger, Ulrich
精神病的维度模型假设了一个连续体，介于精神分裂症和精神分裂症之间。然而，很少有人知道的重叠，在脑功能改变之间的异型性和精神分裂症。54名健康志愿者在一项反扫视任务（一种已知在精神分裂症中受损的认知控制措施）和一项前视任务期间接受了功能性磁共振成像。较高的正向分型与较高的反跳错误率相关。在壳核、丘脑、小脑和视觉皮层的反视动过程中，以及在视觉皮层、补充视野和后顶内沟的前视动过程中，发现了血氧水平依赖性信号降低与高仿型之间的关联。这些研究结果表明，增加型与反跳跃性能下降和降低脑功能的区域也影响精神分裂症，因此提供证据的神经认知和神经生理重叠型和精神分裂症。
Dimensional models of psychosis assume a continuum between schizotypy and schizophrenia. However, little is known about the overlap in brain functional alterations between schizotypy and schizophrenia. Fifty-four healthy volunteers underwent functional magnetic resonance imaging during an antisaccade task, a measure of cognitive control known to be impaired in schizophrenia, and a prosaccade task. Higher positive schizotypy was correlated with higher antisaccade error rates. Associations between reduced blood oxygenation level dependent signal and higher schizotypy were found during antisaccades in the putamen, thalamus, cerebellum, and visual cortex and during prosaccades in the visual cortex, supplementary eye field, and posterior intraparietal sulcus. These findings show that increased schizotypy is associated with decreased antisaccade performance and reduced brain function in regions also affected in schizophrenia, therefore providing evidence of neurocognitive and neurophysiological overlap between schizotypy and schizophrenia.