Differentiation of cysts from solid tumors in the breast with diffuse optical tomography
Differentiation of cysts from solid tumors in the breast with diffuse optical tomography
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DOI：
10.1016/s1076-6332(03)00562-2
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发表时间：
2004-01-01
影响因子：
4.8
通讯作者：
Jiang, HB
中科院分区：
文献类型：
--
作者：
Gu, XJ;Zhang, QZ;Jiang, HB
理由和目标。近红外扩散光学断层扫描（DOT）是一种新兴的成像技术，有可能提供比现有技术更高的对比度分辨率，用于乳腺癌的检测和诊断。到目前为止，DOT的临床评价很大程度上仅限于实体瘤。一项试点临床研究集中在DOT成像乳腺囊肿。材料和方法。六种情况下进行了研究，使用最近开发的紧凑，并行检测DOT系统。利用有限元重建算法获得表征组织吸收和散射的图像。将光学图像与乳腺X线片和超声图像进行比较。在一种情况下，在体外测量的光学性质进行的液体从针抽吸。囊肿与邻近的实质组织之间有明显的对比。对于6例评价，囊肿的位置和大小的光学成像是准确的，并与乳腺X线和超声检查结果一致。在进行抽吸的情况下，囊肿区域的吸收和散射系数成像与从抽吸的液体中测量的吸收和散射系数相比在定量上是准确的。这项初步研究表明，直径为1-4厘米的囊肿可以定量成像。它们可以与实体乳腺肿瘤区分开来，因为与周围正常组织相比，囊肿通常表现出较低的吸收和散射系数，而实体肿瘤表现出与正常组织相关的同时较高的吸收和散射。
Rationale and Objectives. Near-infrared diffuse optical tomography (DOT) is an emerging imaging technology that has the potential to offer enhanced contrast resolution over the existing technologies for detection and diagnosis of breast cancer. Thus far, the clinical evaluation of DOT has been largely limited to solid tumors. A pilot clinical study focused on DOT imaging of breasts with cysts is presented.Materials and Methods. Six cases were studied using the recently developed compact, parallel-detection DOT system. Images characterizing the tissue absorption and scattering were obtained with a finite element-based reconstruction algorithm. The optical images were compared with the mammograms and sonograms. In one case, in vitro measurements of optical properties were conducted for the fluid obtained from needle aspiration.Results. Substantial contrast between cyst and adjacent parenchyma is observed. For the six cases evaluated, the locations and sizes of cysts imaged optically are accurate and consistent with the mammographic and sonographic findings. For the case that aspiration was performed, the absorption and scattering coefficients imaged in the cyst region are quantitatively accurate compared with that measured in vitro from the fluid aspirated.Conclusion. This pilot study shows that cysts ranging from 1-4 cm in diameter can be quantitatively imaged. They can be differentiated from solid breast tumors because cysts generally demonstrate lower absorption and scattering coefficients compared with the surrounding normal tissue, whereas solid tumors show concurrent higher absorption and scattering related to the normal tissue.