Radiation-induced DNA damage and chromatin structure.
Radiation-induced DNA damage and chromatin structure.
复制标题
辐射引起的 DNA 损伤和染色质结构。
DOI：
10.1080/02841860152619070
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Rydberg,B
中科院分区：
文献类型：
--
作者：
Rydberg,B
DNA lesions induced by ionizing radiation in cells are clustered and not randomly distributed. For low linear energy transfer (LET) radiation this clustering occurs mainly on the small scales of DNA molecules and nucleosomes. For example, experimental evidence suggests that both strands of DNA on the nucleosomal surface can be damaged in single events and that this damage occurs with a 10-bp modulation because of protection by histones. For high LET radiation, clustering also occurs on a larger scale and depends on chromatin organization. A particularly significant clustering occurs when an ionizing particle traverses the 30 nm chromatin fiber with generation of heavily damaged DNA regions with an average size of about 2 kbp. On an even larger scale, high LET radiation can produce several DNA double-strand breaks in closer proximity than expected from randomness. It is suggested that this increases the probability of misrejoining of DNA ends and generation of lethal chromosome aberrations.
