Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
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DOI：
10.1212/wnl.48.5.1398
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发表时间：
1997-05-01
期刊：
影响因子：
9.9
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Chen, R;Classen, J;Cohen, LG
我们研究了低频经颅磁刺激（TMS）对人类运动皮层兴奋性的影响。0.1 Hz的TMS持续1小时不改变皮质兴奋性。以0.9 Hz刺激15分钟（810个脉冲），类似于用于在皮质切片制备和体内动物研究中诱导长期抑制（LTD）的参数，导致运动诱发电位（MEP）幅度平均降低19.5%。皮质兴奋性的降低在0.9 Hz刺激结束后持续至少15分钟。这种兴奋性降低的机制可能与LTD相似。TMS诱导的皮质兴奋性降低在癫痫和肌阵挛等疾病中具有潜在的临床应用。兴奋的传播，这可能是癫痫发作的警告信号，发生在一个主题，并没有伴随着MEP幅度增加，这表明兴奋和幅度变化的传播是不同的现象，也表明需要充分的监测，即使在低频率的刺激。
We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD) in cortical slice preparations and in vivo animal studies, led to a mean decrease in motor evoked potential (MEP) amplitude of 19.5%. The decrease in cortical excitability lasted for at least 15 minutes after the end of the 0.9 Hz stimulation. The mechanism underlying this decrease in excitability may be similar to LTD. TMS-induced reduction of cortical excitability has potential clinical applications in diseases such as epilepsy and myoclonus. Spread of excitation, which may be a warning sign for seizures, occurred in one subject and was not accompanied by increased MEP amplitude, suggesting that spread of excitation and amplitude changes are different phenomena and also indicating the need for adequate monitoring even with stimulations at low frequencies.