Drinking or Smoking While Breastfeeding and Later Cognition in Children
Drinking or Smoking While Breastfeeding and Later Cognition in Children
复制标题
DOI：
10.1542/peds.2017-4266
复制
发表时间：
2018-08-01
期刊：
影响因子：
8
通讯作者：
Porter, Melanie
中科院分区：
文献类型：
--
作者：
Gibson, Louisa;Porter, Melanie
背景和目的：虽然产前酒精和尼古丁暴露与儿童认知能力下降有关，但尚未研究哺乳期饮酒与认知能力之间的关系。我们的目的是研究母乳喂养时饮酒或吸烟是否会降低儿童的认知得分。我们假设，增加饮酒或吸烟将与剂量依赖性的认知reductions.METHODS：数据来自澳大利亚长大：澳大利亚儿童的纵向研究。参与者是2004年招募的5107名澳大利亚婴儿，每2年进行一次评估。多变量线性回归分析评估饮酒和吸烟习惯的母乳喂养的母亲和儿童的矩阵推理，皮博迪图片词汇测试，第三版和我是谁？结果：母亲饮酒量增加或风险增加与母乳喂养儿童6至7岁时矩阵推理评分降低相关（B = -0.11; SE = 0.03; 95%置信区间：-0.18至-0.04; P = 0.01）。这种关系在从未母乳喂养的婴儿中不明显（B = -0.02; SE = 0.10; 95%置信区间= -0.20至0.17; P = 0.87）。哺乳期吸烟与任何结果variable.CONCLUSIONS：婴儿暴露于酒精通过母乳可能会导致剂量依赖性降低他们的认知能力。这种减少在6至7岁时观察到，但在10至11岁时没有持续。虽然这种关系很小，但当母亲经常饮酒或酗酒时，它可能具有临床意义。进一步的分析将评估哺乳期饮酒或吸烟与儿童学业、发育、身体和行为结果之间的关系。
BACKGROUND AND OBJECTIVES: Although prenatal alcohol and nicotine exposure are associated with reduced cognition in children, associations between consumption of alcohol during lactation and cognition have not been examined. We aimed to examine whether drinking or smoking while breastfeeding lowers children's cognitive scores. We hypothesized that increased drinking or smoking would be associated with dose-dependent cognitive reductions.METHODS: Data were sourced from Growing Up in Australia: The Longitudinal Study of Australian Children. Participants were 5107 Australian infants recruited in 2004 and assessed every 2 years. Multivariable linear regression analyses assessed relationships between drinking and smoking habits of breastfeeding mothers and children's Matrix Reasoning, Peabody Picture Vocabulary Test-Third Edition and Who Am I? scores at later waves.RESULTS: Increased or riskier wave 1 maternal alcohol consumption was associated with reductions in Matrix Reasoning scores at age 6 to 7 years in children who had been breastfed (B = -0.11; SE = 0.03; 95% confidence interval: -0.18 to -0.04; P = .01). This relationship was not evident in infants who had never breastfed (B = -0.02; SE = 0.10; 95% confidence interval = -0.20 to 0.17; P = .87). Smoking during lactation was not associated with any outcome variable.CONCLUSIONS: Exposing infants to alcohol through breastmilk may cause dose-dependent reductions in their cognitive abilities. This reduction was observed at age 6 to 7 years but was not sustained at age 10 to 11 years. Although the relationship is small, it may be clinically significant when mothers consume alcohol regularly or binge drink. Further analyses will assess relationships between alcohol consumption or tobacco smoking during lactation and academic, developmental, physical, and behavioral outcomes in children.