Chemokine signaling in cancer: Implications on the tumor microenvironment and therapeutic targeting.
Chemokine signaling in cancer: Implications on the tumor microenvironment and therapeutic targeting.
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发表时间：
2009-04
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通讯作者：
Stacey L. Hembruff;N. Cheng
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作者：
Stacey L. Hembruff;N. Cheng
趋化因子是一种可溶性因子，在炎症反应和防御外来病原体过程中调节免疫细胞募集发挥重要作用。一些趋化因子信号通路的失调控表达和活性与癌症进展有关，包括：CCL2、CCL5、CXCL1和CXCL12。虽然过去的研究主要集中在这些趋化因子信号通路在调节免疫反应中的作用，但新兴的研究表明，这些分子调节多种细胞过程，包括血管生成和上皮细胞生长和存活的调节。新的证据表明，趋化因子对癌症的进展至关重要，并在肿瘤微环境中显示出复杂而多样的功能。本文将重点介绍趋化因子信号在调节癌症微环境中的作用，并讨论靶向或传递趋化因子在癌症治疗中的应用。
Chemokines are soluble factors shown to play important roles in regulating immune cell recruitment during inflammatory responses and defense against foreign pathogens. De-regulated expression and activity of several chemokine signaling pathways have been implicated in cancer progression, including: CCL2, CCL5, CXCL1 and CXCL12. While studies in the past have focused the role of these chemokine signaling pathways in regulating immune responses, emerging studies show that these molecules regulate diverse cellular processes including angiogenesis, and regulation of epithelial cell growth and survival. New evidence indicates that chemokines are critical for cancer progression and indicate complex and diverse functions in the tumor microenvironment. This review will focus on the contributions of chemokine signaling in regulating cancer microvironment and discuss the utility of targeting or delivering chemokines in cancer therapeutics.