The effect of heterogeneity in measles vaccination on population immunity
The effect of heterogeneity in measles vaccination on population immunity
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DOI：
10.1017/s0950268804002080
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发表时间：
2004-08-01
影响因子：
4.2
通讯作者：
Grenfell, BT
中科院分区：
文献类型：
--
作者：
Glass, K;Kappey, J;Grenfell, BT
总体疫苗接种水平高有时掩盖了小范围的覆盖率低。我们采用了一个元人口框架来模拟人口的局部聚集，并利用它来研究疫苗接种异质性的影响。最近在荷兰一个疫苗接种水平较低的社区进行的抗体水平调查使我们能够评估本地和远距离感染性接触者的相对重要性，从而确定元人群模型中可行的聚集水平。在聚合模型中，我们发现疫苗接种覆盖率的异质性可能导致未接种疫苗的个体的感染率大大增加，同时感染的平均年龄下降。
High overall vaccination levels sometimes hide pockets of poor coverage. We adopted a meta-population framework to model local aggregation of populations, and used this to investigate the effects of vaccination heterogeneity. A recent survey of antibody levels in a community with low vaccination levels in The Netherlands enabled us to assess the relative importance of local and long-range infective contacts, and thus identify feasible levels of aggregation in the meta-population model. In the aggregated model, we found that heterogeneity in vaccination coverage can lead to a much increased rate of infection among unvaccinated individuals, with a simultaneous drop in the average age at infection.