Vascular amyloid of unknown origin and senile transthyretin amyloid in the lung and gastrointestinal tract of old age: Histological and immunohistochemical studies
Vascular amyloid of unknown origin and senile transthyretin amyloid in the lung and gastrointestinal tract of old age: Histological and immunohistochemical studies
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老年肺和胃肠道中来源不明的血管淀粉样蛋白和老年运甲状腺素蛋白淀粉样蛋白：组织学和免疫组织化学研究
DOI：
10.1046/j.1440-1827.2001.01213.x
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发表时间：
2001
影响因子：
2.2
通讯作者：
T. Ishihara
中科院分区：
文献类型：
--
作者：
Hironobu Matsutani;Y. Hoshii;M. Setoguchi;H. Kawano;T. Gondo;Mutsuo Takahashi;T. Yokota;T. Ishihara
对 64 名 80 岁及以上尸检个体（年龄范围：80-92 岁；平均：83.3 岁）的组织学和免疫组织化学特征以及淀粉样蛋白沉积在肺和胃肠道组织中的发生率进行了调查。使用抗淀粉样蛋白 A、运甲状腺素蛋白、免疫球蛋白 λ 和 κ 轻链淀粉样原纤维蛋白、β2-微球蛋白、β 蛋白、载脂蛋白 AI、载脂蛋白 AII、心房钠尿肽、载脂蛋白 E 和淀粉样蛋白 P 成分的抗体进行免疫组织化学检查。 5 例（7.8%）观察到运甲状腺素蛋白淀粉样纤维蛋白（ATTR）沉积。 26例（40.6%）在胃肠道静脉中观察到来源不明的胃肠道淀粉样蛋白沉积。就分布模式而言，该淀粉样蛋白被认为是门脉淀粉样蛋白。 12例（18.8%）发现不明原因的肺血管淀粉样沉积物。这些淀粉样蛋白沉积物主要存在于肺部中等大小的静脉中，除了载脂蛋白E和淀粉样蛋白P成分外，不与任何针对淀粉样原纤维蛋白的抗体发生反应。 26例显示门静脉淀粉样蛋白的病例中有11例（42.3%）也显示出来源不明的肺血管淀粉样蛋白。肺血管淀粉样沉积物在形态特征及其与血管中弹性纤维的关系方面与门脉淀粉样沉积物相似。对肺血管淀粉样蛋白和门静脉淀粉样蛋白的进一步形态学研究和生化分析将解决它们的起源和关系问题。
The histological and immunohistochemical characteristics and the incidence of amyloid deposits in the tissues of the lung and gastrointestinal tract were investigated in 64 autopsied individuals who were 80 years and older (age range: 80–92 years; mean: 83.3 years). Immunohistochemical examination was performed with antibodies against amyloid A, transthyretin, immunoglobulin λ and κ light chain amyloid fibril proteins, β2‐microglobulin, β protein, apolipoprotein AI, apolipoprotein AII, atrial natriuretic peptide, apolipoprotein E, and amyloid P component. Transthyretin amyloid fibril protein (ATTR) deposits were observed in five cases (7.8%). Gastrointestinal amyloid deposits of unknown origin were observed in the veins of the gastrointestinal tract in 26 cases (40.6%). This amyloid was regarded as portal amyloid with respect to distribution pattern. Pulmonary vascular amyloid deposits of unknown origin were observed in 12 cases (18.8%). These amyloid deposits were found mainly in medium‐sized veins in the lungs and did not react with any antibodies against amyloid fibril proteins except apolipoprotein E and amyloid P component. Eleven of the 26 cases (42.3%) showing portal amyloid also showed pulmonary vascular amyloid of unknown origin. The pulmonary vascular amyloid deposits were similar to the portal amyloid deposits with respect to their morphological features and their relation to elastic fibers in the vessels. Further morphological investigation and biochemical analysis of the pulmonary vascular amyloid and portal amyloid will resolve questions of their origins and relation.
DOI：
10.1073/pnas.84.11.3881
发表时间：
1987-06-01
影响因子：
11.1
作者：
WESTERMARK, P;WERNSTEDT, C;JOHNSON, KH
通讯作者：
JOHNSON, KH