α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies-Part 2
α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies-Part 2
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DOI：
10.2967/jnumed.117.204651
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发表时间：
2018-07-01
影响因子：
9.3
通讯作者：
Lewis, Jason S.
中科院分区：
文献类型：
--
作者：
Poty, Sophie;Francesconi, Lynn C.;Lewis, Jason S.
使用放射源向疾病部位提供细胞毒性电离辐射可以追溯到世纪早期，当时发现了镭及其生理效应。α-发射体在临床肿瘤学领域中对于放射治疗应用特别感兴趣。本综述的第一部分探讨了基本的放射化学，高细胞杀伤能力，α发射放射性核素的可用性，以及放射性标记方法和子体再分布等障碍。本综述的第二部分将概述α-发射体在临床前和临床研究中最有前途和最新的用途。
The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. alpha-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of alpha-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of alpha-emitters in preclinical and clinical studies.