Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin
Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin
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DOI：
10.1007/s40618-016-0506-9
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发表时间：
2016-11-01
影响因子：
5.4
通讯作者：
Masella, R.
中科院分区：
文献类型：
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作者：
Santangelo, C.;Filesi, C.;Masella, R.
特级初榨橄榄油（EVOO）中天然含有的酚类化合物已被证明具有抗炎和抗氧化特性。本研究旨在评价富含多酚的特级初榨橄榄油（EVOO）（高多酚EVOO，HP-EVOO）对超重2型糖尿病（T2 D）患者代谢控制和特异性促/抗炎脂肪因子产生的影响。在前4周（洗脱期），要求他们食用精制橄榄油（ROO，多酚不可检测），然后在剩余的4周内用HP-EVOO（25 mL/天，577 mg酚类化合物/kg）代替ROO。人体测量参数、空腹血糖、糖化血红蛋白（HbA 1c）、高敏C反应蛋白、血脂谱、肝功能和TNF-α、IL-6、脂联素的血清水平，在每4周结束时评估visfatin和apelin。HP-EVOO消耗显著降低空腹血糖（P = 0.023）和HbA 1c（P = 0.039）水平以及BMI（P = 0.012）和体重（P = 0.012）。HP-EVOO摄入确定了血清天冬氨酸转氨酶（AST，P = 0.0056）和丙氨酸转氨酶（ALT，P = 0.024）水平的降低。HP-EVOO摄入后血清内脂素水平显著降低（P = 0.0021）。每日摄入富含多酚的EVOO可能改善超重T2 D患者的代谢控制和循环炎性脂肪因子谱。
Phenolic compounds naturally contained in extra-virgin olive oil (EVOO) have demonstrated anti-inflammatory and antioxidant properties. The present study aimed at evaluating the effects of a polyphenol-rich extra-virgin olive oil (EVOO) (high-polyphenol EVOO, HP-EVOO) on the metabolic control and the production of specific pro-/anti-inflammatory adipokines in overweight patients with type 2 diabetes mellitus (T2D).Eleven overweight T2D patients not in treatment with insulin were invited to follow their habitual diet for a total of 8 weeks. During the first 4 weeks (wash-out period), they were asked to consume refined olive oil (ROO, polyphenols not detectable) and then to replace ROO with HP-EVOO (25 mL/day, 577 mg of phenolic compounds/kg) for the remaining 4 weeks. Anthropometric parameters, fasting glycaemia, glycated haemoglobin (HbA1c), high-sensitive C-reactive protein, plasma lipid profile, liver function and serum levels of TNF-alpha, IL-6, adiponectin, visfatin and apelin were assessed at the end of each 4-week period.HP-EVOO consumption significantly reduced fasting plasma glucose (P = 0.023) and HbA1c (P = 0.039) levels as well as BMI (P = 0.012) and body weight (P = 0.012). HP-EVOO ingestion determined a reduction in serum level of aspartate aminotransferase (AST, P = 0.0056) and alanine aminotransferase (ALT, P = 0.024). Serum visfatin levels strongly decreased after HP-EVOO ingestion (P = 0.0021).Daily consumption of polyphenol-rich EVOO might improve metabolic control and circulating inflammatory adipokines profile in overweight T2D patients.