Hypothermia
Hypothermia
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DOI：
10.1016/j.siny.2007.01.022
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发表时间：
2007-08-01
影响因子：
3
通讯作者：
Edwards, A. D.
中科院分区：
文献类型：
--
作者：
Azzopardi, D.;Edwards, A. D.
实验研究表明，在缺氧缺血性损伤后，轻度诱导的低体温-体温降低约3 IC-保护脑能量代谢，减少脑组织损伤并改善神经功能。在足月和近足月新生儿中进行的随机试验表明，轻度低温治疗是安全的，可以提高18个月龄内无残疾的生存率。虽然最佳的开始时间，深度和持续时间，以及冷却的方法是不确定的，在没有具体的治疗，许多临床医生希望考虑治疗窒息的婴儿与低温。现在需要提供指导，以促进统一的做法，以避免不适当的治疗，并促进在未来的研究窒息后的神经保护的持续合作。如果目前的试验结果得到其他正在进行的研究结果的证实，随着随访时间的延长，这种治疗对婴儿、他们的家庭和卫生资源的短期和长期影响将是相当大的。(C)2007爱思唯尔有限公司保留所有权利。
Experimental studies show that, following hypoxic ischaemic injury, mild induced hypothermia-a reduction of body temperature by about 3 IC-preserves cerebral energy metabolism, reduces cerebral tissue injury and improves neurological function. Randomized trials in full-term and near-full-term newborns suggest that treatment with mild hypothermia is safe and improves survival without disabilities up to 18 months of age. Although the optimal time of initiation, the depth and duration, and the method of cooling are uncertain, in the absence of specific treatments many clinicians will wish to consider treating asphyxiated infants with hypothermia. Guidance now needs to be provided to promote uniform practice, to avoid inappropriate treatment and to foster continuing collaboration in future studies of neuroprotection following asphyxia. If the promising results of the current trials are confirmed by the findings from other on-going studies, with longer follow-up, the impact of such a treatment on the babies, their families and health resources in the shorter and longer terms will be considerable. (C) 2007 Elsevier Ltd. All rights reserved.