SEARCH international case-control study of childhood brain tumours: role of index pregnancy and birth, and mother's reproductive history.
SEARCH international case-control study of childhood brain tumours: role of index pregnancy and birth, and mother's reproductive history.
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SEARCH 儿童脑肿瘤国际病例对照研究：怀孕和出生的影响以及母亲的生育史。
DOI：
10.1046/j.1365-3016.1999.00195.x
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Preston-Martin,S
中科院分区：
文献类型：
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作者：
McCredie,M;Little,J;Cotton,S;Mueller,B;Peris-Bonet,R;Choi,NW;Cordier,S;Filippini,G;Holly,EA;Modan,B;Arslan,A;Preston-Martin,S
在国际癌症研究机构（IARC）的人类癌症相关环境因素监测（ESTA）计划的主持下，开展了一系列儿童脑肿瘤（CBT）的协调人群病例对照研究，以评估与指数妊娠和出生特征以及母亲生育史相关的风险。受试者包括1218例0-19岁的病例和2223例对照。风险评估通过无条件logistic回归计算，调整年龄，性别，中心和母亲的受教育年限，所有类型的CBT组合以及组织病理学定义的四组（星形胶质细胞肿瘤、大脑原始神经外胚层肿瘤、“其他胶质细胞”肿瘤和“其他组织学类型”）和5个年龄组（0-1、0-4、5-9、10-14、15-19岁）。使用麻醉剂“气体”与CBT风险增加相关（OR = 1.5，95% CI [1.1，2.0]），在0-4岁儿童（OR = 2.4，95% CI [1.4，4.1]）和星形胶质细胞肿瘤（OR = 1.6，95% CI [1.1，2.2]）中明显，其他组织学组的相对风险无显著增加。 然而，并非所有中心特异性相对风险均升高。没有其他方面的指数怀孕，分娩和新生儿早期或母亲的以前的生育史与CBT的风险。
A series of co‐ordinated population‐based case–control studies of childhood brain tumours (CBT) was undertaken under the auspices of the Surveillance of Environmental Aspects Related to Cancer in Humans (SEARCH) programme of the International Agency for Research on Cancer (IARC) to evaluate,inter alia, the risk in relation to characteristics of the index pregnancy and birth, and maternal reproductive history. Subjects comprised 1218 cases aged 0–19 years and 2223 controls. Risk estimates were calculated by unconditional logistic regression, adjusted for age, sex, centre and mother’s years of schooling, for all types of CBT combined as well as for four groups defined by histopathology (astroglial tumours, primitive neuroectodermal tumours of the brain, ‘other glial’ tumours and ‘other histological types’) and for five age groups (0–1, 0–4, 5–9, 10–14, 15–19 years). Use of anaesthetic ‘gas’ was associated with an increased risk of CBT (OR = 1.5, 95% CI [1.1, 2.0]), apparent in children aged 0–4 years (OR = 2.4, 95% CI [1.4, 4.1]) and for astroglial tumours (OR = 1.6, 95% CI [1.1, 2.2]) with non‐significantly increased relative risks for each of the other histological groups. However, not all centre‐specific relative risks were elevated. No other aspect of the index pregnancy, delivery and early neonatal period or of the mother’s previous reproductive history was associated with risk for CBT.