The mechanism(s) of hypoxic pulmonary vasoconstriction:: Potassium channels, redox O2 sensors, and controversies
The mechanism(s) of hypoxic pulmonary vasoconstriction:: Potassium channels, redox O2 sensors, and controversies
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DOI：
10.1152/nips.01388.2002
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发表时间：
2002-08-01
期刊：
影响因子：
--
通讯作者：
Michelakis, E
中科院分区：
文献类型：
--
作者：
Archer, S;Michelakis, E
肺血管收缩功能减退使灌注与通气相匹配，并优化全身氧合。Pot的变化由肺动脉平滑肌细胞中的血管氧化还原O-2传感器感知，可能在线粒体内。这会产生一个信号来调节氧化还原敏感性K+通道，从而控制膜电位、Ca 2+进入和张力。
Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in Pot are sensed by a vascular redox O-2 sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K+ channels, thereby controlling membrane potential, Ca2+ entry, and tone.