A hybrid approach to multi-scale modelling of cancer
A hybrid approach to multi-scale modelling of cancer
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DOI：
10.1098/rsta.2010.0173
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发表时间：
2010-11
期刊：
影响因子：
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通讯作者：
J. Osborne;A. Walter;S. K. Kershaw;Gary R. Mirams;A. Fletcher;P. Pathmanathan;D. Gavaghan;O. Jensen;P. Maini;H. Byrne
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文献类型：
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作者：
J. Osborne;A. Walter;S. K. Kershaw;Gary R. Mirams;A. Fletcher;P. Pathmanathan;D. Gavaghan;O. Jensen;P. Maini;H. Byrne
在本文中，我们回顾了实体肿瘤生长的多尺度模型，并讨论了跟踪单个细胞的中间框架。通过关注健康结肠隐窝的细胞动力学及其突变、癌细胞的侵袭，我们比较了细胞中心、细胞顶点和细胞增殖和运动的连续模型。所有模型都重现了健康隐窝的基本特征：细胞在隐窝基部附近增殖，向上迁移，并在靠近顶部的地方脱落。这些模型用于建立突变细胞能够通过自上而下或自下而上入侵在隐窝中定植的条件。虽然连续体模型更快、更容易实施，但很难将系统参数与可测量的生物物理量联系起来。相反，多尺度模型中固有的更多细节意味着可以纳入实验推导的参数，因此，这些模型为理解正常和患病的隐窝、测试和确定新的治疗靶点以及预测其影响提供了更大的范围。
In this paper, we review multi-scale models of solid tumour growth and discuss a middle-out framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we compare a cell-centre, a cell-vertex and a continuum model of cell proliferation and movement. All models reproduce the basic features of a healthy crypt: cells proliferate near the crypt base, they migrate upwards and are sloughed off near the top. The models are used to establish conditions under which mutant cells are able to colonize the crypt either by top-down or by bottom-up invasion. While the continuum model is quicker and easier to implement, it can be difficult to relate system parameters to measurable biophysical quantities. Conversely, the greater detail inherent in the multi-scale models means that experimentally derived parameters can be incorporated and, therefore, these models offer greater scope for understanding normal and diseased crypts, for testing and identifying new therapeutic targets and for predicting their impacts.