Early life maltreatment affects intrinsic neural function in mothers.
Early life maltreatment affects intrinsic neural function in mothers.
复制标题
生命早期的虐待会影响母亲的内在神经功能。
DOI：
10.1016/j.jpsychires.2021.09.004
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发表时间：
2021
影响因子：
4.8
通讯作者：
Herpertz,SabineC
中科院分区：
文献类型：
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作者：
Schneider,Isabella;Neukel,Corinne;Bertsch,Katja;Fuchs,Anna;Möhler,Eva;Zietlow,Anna-Lena;Brunner,Romuald;Wolf,RobertChristian;Herpertz,SabineC
早期生活中的虐待（ELM）对父母的大脑功能有影响，并与母亲敏感性受损有关。在这里，我们调查了ELM对内在神经功能的影响，以及它与母亲的敏感性的关联，而母亲目前没有精神疾病发作。27位ELM母亲和29位无ELM母亲进行了静息态功能磁共振成像检查，然后进行低频波动幅度，区域均匀性和基于种子的功能连接分析。母亲和学龄儿童之间的视频互动进行了评估的基础上情绪可用性量表的母亲的敏感性。区域和功能连接的措施被用来调查内在活动和情绪可用性之间的关联。与未患ELM的母亲相比，患有ELM的母亲表现出母亲敏感性降低，右侧上级额回、左侧楔前叶、左侧枕中回和顶叶皮质（左侧角回和右侧缘上回）的内在神经活动较低（p <0.001，全脑）。在所有参与者中，额上上级回的低频波动幅度与母亲的敏感性呈正相关（p = .002）。这些数据表明，即使在目前心理健康的母亲中，ELM也存在行为和神经特征。特别是，ELM的影响在涉及社会认知和执行控制的不同大脑区域被发现。这些ELM相关的改变可能与母亲的行为。
Early life maltreatment (ELM) has an impact on brain functions involved in parenting and is associated with impaired maternal sensitivity. Here, we investigated the influence of ELM on intrinsic neural function and its associations with maternal sensitivity in mothers without a current episode of a mental disorder. Twenty-seven mothers with ELM and 29 mothers without ELM were examined using resting-state functional magnetic resonance imaging, followed by Amplitude of Low Frequency Fluctuations, regional homogeneity and seed-based functional connectivity analyses. Videotaped interactions between mothers and their school-aged children were conducted to assess maternal sensitivity based on the Emotional Availability Scales. Regional and functional connectivity measures were used to investigate associations between intrinsic activity and emotional availability. Mothers with ELM showed reduced maternal sensitivity and lower intrinsic neural activity in the right superior frontal gyrus, the left precuneus, the left middle occipital gyrus, and the parietal cortex (left angular and right supramarginal gyrus) compared to mothers without ELM (p < .001, whole-brain). Amplitude of Low Frequency Fluctuations in the superior frontal gyrus was positively associated with maternal sensitivity across all participants (p = .002). The data suggest a behavioral and neural signature of ELM even in currently mentally healthy mothers. In particular, effects of ELM were found in distinct brain regions involved in social cognition and executive control. These ELM-related alterations may be associated with maternal behavior.