Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis?
Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis?
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DOI：
10.1371/journal.pone.0146344
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Pavesio C
中科院分区：
文献类型：
--
作者：
Agrawal R;Salman M;Tan KA;Karampelas M;Sim DA;Keane PA;Pavesio C
使用增强深度成像（EDI）-光学相干断层扫描（OCT）扫描的图像二值化工具计算脉络膜血管指数（CVI），作为监测全葡萄膜炎进展的非侵入性光学工具，并使用自定义图像分析软件研究EDI-OCT扫描的体积数据的效用。在这项回顾性队列研究中，在基线和3个月随访时对19例全葡萄膜炎患者的双眼进行分段EDI-OCT扫描，并与正常眼的EDI-OCT扫描进行比较。中心凹下脉络膜区分为管腔区和基质间质区。脉络膜血管指数（CVI）定义为LA占整个外切中心凹下脉络膜面积（TCA）的比例。基线时平均脉络膜厚度为265.5±100.1μm，3个月随访时为278.4±102.6μm（p = 0.06）。研究眼和对照眼之间的TCA无统计学显著差异（p = 0.08）。对照组基线时的CVI为66.9±1.5%，随访时为66.4±1.5%。葡萄膜炎眼基线时的CVI为74.1±4.7%，3个月随访时为69.4±4.8%（p<0.001）。葡萄膜炎眼的CVI变化%为6.2 ±3.8（4.3至8.0），显著高于对照眼的CVI变化%（0.7±1.1，0.2至1.3，p<0.001）。该研究报告复合OCT衍生参数和CVI作为监测全葡萄膜炎进展的一种可能的新工具。CVI可以进一步验证在更大的研究作为一种新的光学工具来量化脉络膜血管状态。
To compute choroidal vascularity index (CVI) using an image binarization tool on enhanced depth imaging (EDI)-optical coherence tomography (OCT) scans as a non-invasive optical tool to monitor progression in panuveitis and to investigate the utility of volumetric data from EDI-OCT scans using custom image analysis software. In this retrospective cohort study, segmented EDI-OCT scans of both eyes in 19 patients with panuveitis were taken at baseline and at 3-month follow-up and were compared with EDI-OCT scans of normal eyes. Subfoveal choroidal area was segmented into luminal (LA) and stromal interstitial area (SA). Choroidal vascularity index (CVI) was defined as the proportion of LA to the total circumscribed subfoveal choroidal area (TCA). The mean choroidal thickness was 265.5±100.1μm at baseline and 278.4±102.6μm at 3 months follow up (p = 0.06). There was no statistically significant difference in TCA between study and control eyes (p = 0.08). CVI in the control group was 66.9±1.5% at baseline and 66.4±1.5% at follow up. CVI was 74.1±4.7% at baseline and 69.4±4.8% at 3 months follow up for uveitic eyes (p<0.001). The % change in CVI was 6.2 ±3.8 (4.3 to 8.0) for uveitic eyes, which was significantly higher from % change in CVI for control eyes (0.7±1.1, 0.2 to 1.3, p<0.001). The study reports composite OCT-derived parameters and CVI as a possible novel tool in monitoring progression in panuveitis. CVI may be further validated in larger studies as a novel optical tool to quantify choroidal vascular status.