The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD
The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD
复制标题
循环中CXCL5水平升高与COPD患者和吸烟诱发的COPD小鼠模型的肺功能下降有关
DOI：
10.1080/07853890.2019.1639809
复制
发表时间：
2019-07-16
影响因子：
4.4
通讯作者：
Wen, Fuqiang
中科院分区：
文献类型：
--
作者：
Chen, Jun;Dai, Luqi;Wen, Fuqiang
C-X-C基序趋化因子5主要是中性粒细胞的趋化作用，先前显示慢性阻塞性肺疾病患者支气管肺泡灌洗液中C-X-C基序趋化因子5升高。然而，C-X-C基序趋化因子5水平是否与慢性阻塞性肺疾病患者或小鼠模型的肺功能下降相关尚不清楚。方法采用香烟烟雾暴露诱导小鼠模型。取慢性阻塞性肺疾病患者和小鼠模型的血浆/血清和支气管肺泡灌洗液；C-X-C基序趋化因子5水平分别与肺功能和粒细胞集落刺激因子水平相关。结果慢性阻塞性肺疾病患者和小鼠模型血浆/血清和支气管肺泡灌洗液中C-X-C基序趋化因子5水平升高并与粒细胞集落刺激因子水平相关。C-X-C基序趋化因子5的循环水平与患者和小鼠肺功能下降相关。结论粒细胞集落刺激因子可能与C-X-C基序趋化因子5协同参与慢性阻塞性肺疾病中性粒细胞炎症的发病机制。循环C-X-C基序趋化因子5可能作为一种潜在的血液生物标志物，对慢性阻塞性肺疾病的初步筛查和诊断增加额外的适度预测价值。循环C-X-C基序趋化因子5可能作为一种潜在的血液生物标志物，在COPD的初步筛查和诊断中增加额外的适度预测价值。粒细胞集落刺激因子可能与C-X-C基序趋化因子5协同参与慢性阻塞性肺疾病中性粒细胞炎症的发病机制。
Abstract Introduction C-X-C motif chemokine 5 is primarily chemotactic for neutrophils and previously shown to increase in the bronchoalveolar lavage fluid of patients with chronic obstructive pulmonary disease. However, whether C-X-C motif chemokine 5 levels correlate with lung function decline in patients or mouse model of chronic obstructive pulmonary disease was not clear. Methods The mouse model was induced by cigarette smoke exposure. Plasma/serum and bronchoalveolar lavage fluid were obtained from patients and mouse model of chronic obstructive pulmonary disease; C-X-C motif chemokine 5 levels were assessed and correlated with lung functions and granulocyte-colony stimulating factor levels, respectively. Results The C-X-C motif chemokine 5 levels increased and correlated to granulocyte-colony stimulating factor levels in both plasma/serum and bronchoalveolar lavage fluid obtained from patients and mouse model of chronic obstructive pulmonary disease. Circulating levels of C-X-C motif chemokine 5 correlated to lung functions decline in patients and mouse model. Conclusions Granulocyte-colony stimulating factor might coordinate with C-X-C motif chemokine 5 in the pathogenesis of neutrophilic inflammation in chronic obstructive pulmonary disease. Circulating C-X-C motif chemokine 5 might serve as a potential blood-based biomarker to add additional modest predictive value on the preliminary screening and diagnosis of chronic obstructive pulmonary disease. Key messages Circulating C-X-C motif chemokine 5 might serve as a potential blood-based biomarker to add additional modest predictive value on the preliminary screening and diagnosis of COPD. Granulocyte-colony stimulating factor might coordinate with C-X-C motif chemokine 5 in the pathogenesis of neutrophilic inflammation in chronic obstructive pulmonary disease.