Synchrotron radiation therapy of malignant brain glioma loaded with an iodinated contrast agent:: First trial on rats bearing F98 gliomas
Synchrotron radiation therapy of malignant brain glioma loaded with an iodinated contrast agent:: First trial on rats bearing F98 gliomas
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DOI：
10.1016/j.ijrobp.2003.07.007
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发表时间：
2003-12-01
影响因子：
7
通讯作者：
Estève, F
中科院分区：
文献类型：
--
作者：
Adam, JF;Elleaume, H;Estève, F
目的：通过向患者注入碘化造影剂，并以计算机断层扫描（CT）模式用千伏X射线照射，可以提高递送至脑肿瘤的辐射剂量。同步辐射源能提供单色可调的高强度光束，是这种治疗的理想选择。本研究的目的是在体内评估这种新型放射治疗模式——同步辐射CT治疗的有效性。
方法和材料：对18只费希尔344大鼠进行10⁵个F98胶质瘤细胞的颅内植入。6只大鼠为未治疗的对照组，6只仅接受放射治疗（在50 keV下通过单次断层照射在肿瘤处给予10 Gy），6只在持续注入碘化造影剂的情况下接受相同的放射治疗。
结果：在放射治疗期间接受造影剂的大鼠比仅接受放射治疗的大鼠存活时间显著更长（p = 0.025）。平均存活时间（平均值±标准差）分别为12.3±0.8天、14.8±2.8天和18.2±1.3天；中位存活时间分别为12.5天、15天和18天（分别为未治疗对照组、未用碘照射组、用碘照射组）。未用碘或用碘照射的大鼠寿命分别增加了20%和44%。
结论：这种利用同步辐射提高脑肿瘤辐射剂量的方法显著提高了存活率，看起来很有前景。（C）2003年爱思唯尔公司
Purpose: Enhancement of the radiation dose delivered to a brain tumor can be achieved by infusing an iodinated contrast agent to the patient and irradiating with kilovoltage X-rays in computed tomography (CT) mode. Synchrotron sources, providing monochromatic tunable intense beams, are ideal for this treatment. The aim of this study is to assess in vivo the efficiency of this novel radiotherapy modality, Synchrotron Radiation CT-Therapy.Methods and Materials: Intracranial implantations of 10(5) F98 glioma cells were performed on 18 Fisher 344 rats. Six rats were untreated controls, six received radiotherapy alone (10 Gy in the tumor by single fraction tomographic irradiation at 50 keV), and six received the same radiotherapy treatment under a continuous infusion of iodinated contrast agent.Results: The rats that received contrast agent during radiotherapy survived significantly longer than rats that received radiotherapy alone (p = 0.025). Mean survival times (mean +/- SD) were 12.3 +/- 0.8, 14.8 +/- 2.8, and 18.2 +/- 1.3 days; median survival times were 12.5, 15, and 18 days (untreated controls, irradiated without iodine, irradiated with iodine, respectively). The increase in life spans was 20% and 44% for the rats irradiated without or with iodine, respectively.Conclusions: This method of radiation dose enhancement in brain tumors with synchrotron radiation significantly increases survival and appears highly promising. (C) 2003 Elsevier Inc.