The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress
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DOI：
10.1159/000360102
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Alver, Ahmet
中科院分区：
文献类型：
--
作者：
Durmus, Ahmet;Mentese, Ahmet;Alver, Ahmet
目的：比较真性红细胞增多症（PV）患者与健康志愿者的氧化应激参数，探讨PV患者血管事件与氧化状态参数如总氧化状态（TOS）、总抗氧化状态、氧化应激指数（OSI）和丙二醛（MDA）之间的可能关系。材料与方法：纳入35例PV患者（男性20例，女性15例）和20例健康志愿者（男性11例，女性9例）。采用分光光度法测定患者在诊断时和治疗后6个月的氧化状态参数，其中高危组和低危组分别采用放血和100mg /天乙酰水杨酸加或不加羟基脲治疗。将这些参数与健康对照进行比较，并相互比较，以获得治疗前后的数值。此外，在诊断过程中，将有血管事件史的PV患者与无血管事件史的患者的氧化状态参数进行比较。结果：患者诊断时TOS、OSI、MDA值均显著高于对照组。在放血和100 mg/d乙酰水杨酸治疗6个月后，患者的TOS、OSI和MDA值较治疗前显著降低。有血管事件史的患者TOS和OSI水平明显高于无血管事件史的患者。结论：PV患者氧化应激参数升高。(C) 2014 S. Karger AG，巴塞尔
Objective: This study was designed to compare the oxidative stress parameters of patients with polycythemia vera (PV) to those of healthy volunteers and to investigate the probable relationship between vascular events and parameters of oxidative status such as total oxidative status (TOS), total antioxidant status, oxidative stress index (OSI) and malondialdehyde (MDA) in PV patients. Material and Methods: Thirty-five PV patients (20 males and 15 females) and 20 healthy volunteers (11 males and 9 females) were enrolled. The oxidative status parameters of the patients were measured by spectrophotometric analyses at the time of diagnosis and at 6 months after treatment which consisted of phlebotomy and 100 mg/day acetyl salicylic acid with or without hydroxyurea for the high-and low-risk disease group, respectively. These parameters were compared both to healthy controls and to each other, in order to obtain the values before and after treatment. In addition, during diagnosis, the oxidative status parameters of patients with PV and a history of a vascular event were compared with those of patients with no history of a vascular event. Results: The TOS, OSI and MDA values were significantly higher in the patients than in the control group at the time of diagnosis. At 6 months after phlebotomy and 100 mg/day acetyl salicylic acid therapy, the TOS, OSI and MDA values were significantly lower in the patients when compared to the pretreatment values. The TOS and OSI levels were notably higher in the patients with a vascular-event history than in those without this history. Conclusion: Oxidative stress parameters were increased in PV patients. (C) 2014 S. Karger AG, Basel