HLA-DP antigens in patients with pauciarticular juvenile rheumatoid arthritis.
HLA-DP antigens in patients with pauciarticular juvenile rheumatoid arthritis.
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少关节型幼年类风湿性关节炎患者的 HLA-DP 抗原。
DOI：
10.1002/art.1780290901
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发表时间：
1986
影响因子：
--
通讯作者：
Glass,DN
中科院分区：
文献类型：
--
作者：
Hoffman,RW;Shaw,S;Francis,LC;Larson,MG;Petersen,RA;Chylack,LT;Glass,DN
对少关节幼年类风湿性关节炎和虹膜睫状体炎患者中最近描述的人类白细胞抗原-DP的分布进行了检测，试图进一步表征免疫遗传学确定的对这种疾病的易感性。患者组HLADPw2抗原频率显著高于对照组(67%vs34%；Fisher‘s Exact检验，优势比3.9P=0.003)。人群研究和家庭研究表明，在这些患者中，这种与HLA-DPw2的关联并不是由于与先前定义的疾病的HL A-D区域标记(HL A-DR5和HL A-DRU8)的连锁不平衡所致。这些数据增加了一种可能性，即对这种形式的幼年类风湿性关节炎的易感性可能受到不止一个与人类白细胞抗原相关的基因的调控。
The distribution of the recently described HLA‐DP antigens was examined in a population of patients with pauciarticular juvenile rheumatoid arthritis and iridocyclitis, in an attempt to further characterize the immunogenetically determined susceptibility to this disease. There was a significantly increased frequency of the HLA‐DPw2 antigen in the patients compared with the controls (67% versus 34%; odds ratio 3.9,P= 0.003 by Fisher's exact test). Population studies and family studies showed that this association with HLA‐DPw2 was not secondary to linkage disequilibrium with the previously defined HLA‐D region markers of disease (HLA‐DR5 and HLA‐DRw8) in these patients. These data raise the possibility that susceptibility to this form of juvenile rheumatoid arthritis may be regulated by more than one HLA‐linked gene.