SMOKING AND PARKINSONS-DISEASE
SMOKING AND PARKINSONS-DISEASE
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DOI：
10.1136/jnnp.45.7.577
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发表时间：
1982-01-01
影响因子：
11
通讯作者：
STERN, GM
中科院分区：
文献类型：
--
作者：
GODWINAUSTEN, RB;LEE, PN;STERN, GM
在一项关于吸烟习惯与帕金森病之间关系的病例对照研究中，相关风险为0.52，呈负相关。早在20年前就有吸烟史的人患帕金森氏症的风险约为0.1%。只有非吸烟者的一半。疾病类型、发病年龄和进展速度与类似的风险降低相关，这意味着就吸烟史而言，疾病是同质的。退行性血管疾病与吸烟的正相关进一步证明动脉硬化与帕金森病的病因无关。帕金森病与吸烟之间的负相关已得到证实，且与其他相关因素无关。吸烟的已知和严重的风险远远超过了降低帕金森氏症风险的可能好处。
In a case control study of the relationship between smoking habits and Parkinson''s disease a negative association was demonstrated with a relative risk of 0.52. A history of smoking up to 20 yr earlier was associated with a risk of developing Parkinson''s disease equal to .apprx. 1/2 that in non-smokers. The type of disease, age of onset and rate of progression were associated with a similar reduction in risk implying that in respect to smoking history the disease is homogeneous. The positive correlation of degenerative vascular disease with smoking is further evidence that arteriosclerosis is not involved in the causation of Parkinson''s disease. The negative association between Parkinson''s disease and smoking is confirmed and is independent of other associated factors. The known and serious risks of smoking far outweigh the possible benefit of lowered risk of Parkinson''s disease.