MiR-106a: Promising biomarker for cancer
MiR-106a: Promising biomarker for cancer
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MiR-106a：有前途的癌症生物标志物
DOI：
10.1016/j.bmcl.2016.10.042
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发表时间：
2016-11-15
影响因子：
2.7
通讯作者：
Pei, Dong-Sheng
中科院分区：
文献类型：
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作者：
Pan, Yao-Jie;Zhuang, Ying;Pei, Dong-Sheng
microRNAs（miRNAs）是一类高度保守的小分子非编码RNA，在细胞增殖、凋亡、代谢、细胞分化、信号转导和肿瘤发生等生物学过程中发挥着重要作用，其中miR-106 a（miRNAs-106 a）是miR-17家族的成员，在多种肿瘤中受到异常调控。本文综述了miR-106 a在细胞增殖、凋亡、细胞周期、侵袭和转移中的作用，以及与靶蛋白的相互作用和相关信号通路。(C)2016爱思唯尔有限公司版权所有
MicroRNAs (miRNAs), which are characterized by highly conserved and small non-coding RNAs, have been a hot spot regarding biological processes such as cellular proliferation, apoptosis and metabolism as well as cellular differentiation, signal transduction and carcinogenesis.MiRNA-106a (miR-106a), a member of the miR-17 family, has been validated to be aberrantly regulated in the diversity of tumors. The purpose of this review is supposed to deliver an intricate overview of miR-106a, including its role in cell proliferation, apoptosis, cell cycle, invasion and metastasis, involvement in drug resistance as well as its interactions with the target proteins and signaling pathways involved. (C) 2016 Elsevier Ltd. All rights reserved.