Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly
Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly
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DOI：
10.1016/j.acn.2005.02.004
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发表时间：
2005-08-01
影响因子：
2.6
通讯作者：
Gordon, E
中科院分区：
文献类型：
--
作者：
Paul, RH;Haque, O;Gordon, E
以前的研究已经检查了皮质下高信号（SH）的影响，脑血管疾病的代理措施，对其他健康的老年人的认知能力。然而，对于这种病理过程的MRI标记物在多大程度上解释了随着年龄的增长几乎普遍发生的特定认知功能的下降，特别是与其他年龄相关的成像标记物有关，仍然存在有限的理解。在本研究中，我们比较了53名老年健康成年人（年龄范围= 50-79）和53名年轻人（年龄范围= 21-40）之间的认知能力。正如预期的那样，与年轻组相比，老年组在大多数认知指标上的表现明显较差。额叶体积和总灰质体积也显着减少老年人相比，年轻人。SH体积始终与老年人的认知功能相关，尽管这种关系仅在相对较小的老年人中最严重的SH患者中才明显。这些数据表明，老年人的SH和认知之间的关系是由一个子集的人谁可能是在血管性认知障碍的最早阶段。此外，研究结果表明，认知老化在很大程度上是由大多数老年人的SH以外的因素决定的。(c)2005年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
Previous studies have examined the impact of subcortical hyperintensities (SH),a proxy measure of cerebrovascular disease, on the cognitive abilities of otherwise healthy older adults. However, there remains a limited understanding as to what extent this MRI marker of pathological processes explains the decline in specific cognitive functions that occur nearly ubiquitously with advanced age, especially in relation to other age-related imaging markers. In the present study we compared cognitive abilities between a sample of 53 older healthy adults (age range= 50-79) and a sample of 53 younger adults (age range= 21-40). As expected, the older group performed significantly worse on most cognitive measures compared to the younger group. Frontal volume and total grey matter volume were also significantly reduced among the older individuals compared to the younger individuals. SH volume was consistently associated with cognitive function in older adults, though, this relationship was evident only for a relatively small subset of older individuals with the most severe SH. These data suggest that the relationship between SH and cognition in the elderly is driven by a subset of individuals who may be in the earliest stages of vascular cognitive impairment. Further, the findings suggest that cognitive aging is largely determined by factors other than SH for most older adults. (c) 2005 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.