Activation of murine macrophages.
Activation of murine macrophages.
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DOI：
10.1002/0471142735.im1402s83
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发表时间：
2008-11
影响因子：
--
通讯作者：
Zhang, Xia
中科院分区：
文献类型：
--
作者：
Mosser, David M;Zhang, Xia
我们对细胞免疫(CMI)的理解揭示了激活的巨噬细胞作为关键免疫效应细胞的重要性。在过去的十年中，我们逐渐认识到巨噬细胞具有显著的可塑性，不同群体的巨噬细胞可以对不同的刺激做出不同的反应。事实上，可能出现的不同巨噬细胞群的数量可能与诱导它们的激活刺激一样不同。其中一些刺激可以指示巨噬细胞杀死微生物(经典激活)，铺设细胞外基质成分以促进伤口愈合(替代激活)，或分泌抗炎细胞因子以终止炎症(调节巨噬细胞)。生化鉴定这些细胞的新方法使人们更好地了解激活的巨噬细胞的异质性。随着我们对不同巨噬细胞群体的了解的增加，基于特定激活巨噬细胞群体的治疗干预的可能性也在增加。
Our understanding of cell mediated immunity (CMI) has revealed the importance of activated macrophages as key immune effector cells. Over the past decade, we have come to realize that macrophages exhibit remarkable plasticity, and different populations of macrophages with distinct physiologies can develop in response to different stimuli. In fact, it is likely that the number of different macrophage populations that can arise may be as diverse as the activating stimuli that induce them. Some of these stimuli can instruct macrophages to kill microbes (classical activation), lay down extracellular matrix components to promote wound healing (alternative activation), or secrete anti-inflammatory cytokines to terminate inflammation (regulatory macrophages). New ways to biochemically identify these cells have led to a better understanding of the heterogeneity of activated macrophages. As our understanding of the various macrophage populations increases, so does the potential for therapeutic intervention based on targeting specific populations of activated macrophages.