Two New C 21 Steroids from Gymnema tingens
Two New C 21 Steroids from Gymnema tingens
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DOI：
10.1002/slct.202202726
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发表时间：
2022-10
期刊：
影响因子：
2.1
通讯作者：
Jin He;Yuen Yao;Meiyu Liu;Guangfeng Liao;Xinkai Yang;Rumei Lu
中科院分区：
文献类型：
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作者：
Jin He;Yuen Yao;Meiyu Liu;Guangfeng Liao;Xinkai Yang;Rumei Lu
从匙羹藤（Gymnema tingens）全草中分离得到两个新的C21甾体化合物，分别命名为12-O-乙酰基-（20 S）-O-（N-甲基）邻氨基苯甲酰基肌节素-5 α，6 β-六羟基曲烷（1）和12-O-乙酰基-（20 S）-O-（N-甲基）邻氨基苯甲酰基肌节素-3-O-β-D-吡喃糖苷（2），以及8个已知化合物（3-10）。新化合物的结构通过广泛的一维和二维核磁共振（NMR）谱与质谱数据建立。测试化合物1 - 9在L 6细胞中的葡萄糖摄取，并且化合物3和4显示出最有效的葡萄糖摄取活性，分别增强2.98倍和3.36倍。
Two new C21steroids, named 12‐O‐acetyl‐(20S)‐O‐(N‐methyl)anthraniloyl sarcostin‐5α,6β‐hexahydroxypregnane (1) and 12‐O‐acetyl‐(20S)‐O‐(N‐methyl)anthraniloyl sarcostin 3‐O‐β‐D‐cymaropyranoside (2), together with eight known compounds (3–10) were isolated from the dried whole plants ofGymnema tingens. The structures of the new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. Compounds1–9were tested for glucose uptake in L6 cells, and compounds3and4showed the most potent glucose uptake activity with the enhancement by 2.98‐ and 3.36‐fold.